ASIS-TOBE Marine Collagen 81 Serum Versus Oxecure Acne Defense Prebio Serum

ASIS-TOBE Marine Collagen 81 Serum Versus Oxecure Acne Defense Prebio Serum

This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This acne serum is formulated around Inulin and Melaleuca Alternifolia Leaf Oil to clear breakouts and calm redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Hydrolyzed Collagen 81%

Water

Glycerin

Propanediol

1,2-Hexanediol

Niacinamide

Camellia Sinensis Leaf Extract

Rosmarinus Officinalis Leaf Extract

Chamomilla Recutita Flower Extract

Centella Asiatica Extract

Glycyrrhiza Glabra Root Extract

Polygonum Cuspidatum Root Extract

Scutellaria Baicalensis Root Extract

Alcohol

Butylene Glycol

Sclerotium Gum

Dioscorea Japonica Root Extract

Tremella Fuciformis Extract

Hydrogenated Lecithin

Betaine

Trehalose

Panthenol

Benzyl Glycol

Sodium Acetylated Hyaluronate

Sodium Hyaluronate

Sodium Hyaluronate Crosspolymer

Trichosanthes Kirilowii Root Extract

Hydroxypropyltrimonium Hyaluronate

Hydrolyzed Glycosaminoglycans

Hydrolyzed Hyaluronic Acid

Hyaluronic Acid

Acetyl Hexapeptide-8

Allantoin

Adenosine

Ethylhexylglycerin

Xanthan Gum

Citrus Aurantium Bergamia Fruit Oil

Limonene

Hydrolyzed Collagen 81%, Water, Glycerin, Propanediol, 1,2-Hexanediol, Niacinamide, Camellia Sinensis Leaf Extract, Rosmarinus Officinalis Leaf Extract, Chamomilla Recutita Flower Extract, Centella Asiatica Extract, Glycyrrhiza Glabra Root Extract, Polygonum Cuspidatum Root Extract, Scutellaria Baicalensis Root Extract, Alcohol, Butylene Glycol, Sclerotium Gum, Dioscorea Japonica Root Extract, Tremella Fuciformis Extract, Hydrogenated Lecithin, Betaine, Trehalose, Panthenol, Benzyl Glycol, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Trichosanthes Kirilowii Root Extract, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Glycosaminoglycans, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Acetyl Hexapeptide-8, Allantoin, Adenosine, Ethylhexylglycerin, Xanthan Gum, Citrus Aurantium Bergamia Fruit Oil, Limonene

Polysorbate 20

Ceramide AP

Caprylhydroxamic Acid

Croton Lechleri Resin Extract

Aloe Barbadensis Leaf Juice

Mannitol

Cellulose

Hydroxypropyl Methylcellulose

Inulin

Yeast Beta-Glucan

Undaria Pinnatifida Extract

PEG-40 Hydrogenated Castor Oil

Melaleuca Alternifolia Leaf Oil

Dipotassium Glycyrrhizate

Lactobacillus/Rye Flour Ferment

Saccharide Isomerate

Glucose

Chondrus Crispus Extract

Hydrolyzed Sodium Hyaluronate

Potassium Hyaluronate

Caprylyl Glycol

Houttuynia Cordata Extract

Pistacia Lentiscus Gum

Lecithin

Morus Alba Root Extract

Artemisia Capillaris Flower Extract

Zizyphus Jujuba Fruit Extract

Taraktogenos Kurzii Seed Oil

Nigella Sativa Seed Oil

Leptospermum Scoparium Branch/Leaf Oil

Potassium Lauroyl Wheat Amino Acids

Palm Glycerides

Capryloyl Glycine

Magnolia Grandiflora Bark Extract

Phenoxyethanol

Sodium Benzoate

Potassium Sorbate

Citric Acid

Sodium Citrate

Water, Polysorbate 20, Propanediol, Sclerotium Gum, Ceramide AP, 1,2-Hexanediol, Caprylhydroxamic Acid, Croton Lechleri Resin Extract, Aloe Barbadensis Leaf Juice, Mannitol, Cellulose, Hydroxypropyl Methylcellulose, Inulin, Yeast Beta-Glucan, Undaria Pinnatifida Extract, Sodium Hyaluronate, PEG-40 Hydrogenated Castor Oil, Melaleuca Alternifolia Leaf Oil, Butylene Glycol, Dipotassium Glycyrrhizate, Lactobacillus/Rye Flour Ferment, Saccharide Isomerate, Xanthan Gum, Glucose, Chondrus Crispus Extract, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Caprylyl Glycol, Houttuynia Cordata Extract, Glycyrrhiza Glabra Root Extract, Scutellaria Baicalensis Root Extract, Pistacia Lentiscus Gum, Lecithin, Glycerin, Alcohol, Morus Alba Root Extract, Artemisia Capillaris Flower Extract, Zizyphus Jujuba Fruit Extract, Taraktogenos Kurzii Seed Oil, Nigella Sativa Seed Oil, Leptospermum Scoparium Branch/Leaf Oil, Potassium Lauroyl Wheat Amino Acids, Palm Glycerides, Capryloyl Glycine, Magnolia Grandiflora Bark Extract, Centella Asiatica Extract, Polygonum Cuspidatum Root Extract, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower Extract, Rosmarinus Officinalis Leaf Extract, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, Citric Acid, Sodium Citrate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

This ingredient is also called ethanol or ethyl alcohol. It is denatured, meaning made undrinkable for cosmetic use.

In formulas, it:

Is it bad for your skin?

The answer comes down to concentration. Patch and wash studies have found highly concentrated alcohol-based hand rubs (60-100%) cause less barrier disruption than washing with a basic detergent like SLS. The only measurable effect in these studies was a temporary dip in skin hydration.

Concentrations below 12-15% in leave-on cosmetics is generally well-tolerated. Concentrations above start to see increased transepidermal water loss (TEWL) and reduced hydration.

In concentrations about 58%, it creates temporary channels in your skin's lipid layers to become more permeable and allow other ingredients to slip through easily.

This ingredient can be up to 80% of the formula in alcohol-based perfumes.

Overall, this ingredient is probably harmless if found lower down an ingredients list but worth side-eyeing if it's high up (especially if your barrier is already struggling).

Alcohol can worsen dry skin, eczema, and oily skin, especially at higher concentrations. This is because it can increase transepidermal water loss and decrease hydration to disrupt the skin barrier.

According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.

True allergic contact dermatitis to ethanol is uncommon, but be sure to patch test if you have dry or sensitive skin.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Camellia Sinensis Leaf Extract (tea extract) is one of the most well-researched plant extracts in skincare with an impressive resume.

Black tea, green tea, and oolong tea are all harvested from the Camellia Sinensis plant.

Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside.

In lab-grown skin models, this translated to younger, healthier, and stronger skin.

There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection.

Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums.

A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity.

The quality of the extract matters a lot here:

Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients.

Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water).

Centella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.

That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.

These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.

Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.

Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.

Here is the short version of what they do in the skin:

So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.

Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:

Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.

Centella is one of the most easygoing actives out there.

It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.

On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.

Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.

But as with any new active, a patch test is still a smart move for very reactive skin.

Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).

The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).

In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.

Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.

Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.

Chamomilla Recutita Flower Extract comes from the Chamomile flower.

Chamomile is rich in antioxidants and has anti-inflammatory properties. Several compounds found in chamomile help with soothing, such as bisbolol.

Antioxidant components in chamomile make it an effective ingredient to help slow the signs of aging. Antioxidants help fight free-radical molecules, or molecules that may damage your skin.

Essential oils from chamomile have been found to improve wound healing due to its antimicrobial properties.

Ancient Greeks and Egyptians used Chamomile to treat skin redness and dryness. Chamomile has also been used to help treat stomach issues.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Hydroxypropyltrimonium Hyaluronate is a positively charged version of hyaluronic acid.

This small change does a lot in a formula:

Regular hyaluronic acid carries a negative charge and so does the surface of your skin. This means the two repel each other and hyaluronic acid can be washed away easily. The positive charge here does the opposite: it makes the ingredient cling to your skin (also called "substantivity") so it keeps hydrating even in rinse-off products where it lays down a light, moisture-holding film.

The research backs this up too; a 2025 clinical study on a shower gel containing 0.1% positively charged hyaluronic acid increased skin hydration by 6.6% versus the baseline and 11.1% versus the placebo. This was measured 6 hours after 1 minute of contact and rinse, and on volunteers with very dry skin.

The same team's lab work showed it adhered to skin far better than unmodified hyaluronic acid (+107% vs. low molecular weight, +23% versus high molecular weight). They also found it increased two proteins tied to skin hydration, aquaporin-3 by 16% and filaggrin by 35%.

A separate 2024 study reached a similar conclusion and credited the hydrating benefits to its film-forming properties.

Both studies used the ingredient at 0.1% which also matches how much it usually shows up in products (at fractions of a percent).

One honesty note worth keeping in mind: the published research comes from the company that manufactures the ingredient so independent data would strengthen the picture. However, the results are consistent and the mechanism makes sense.

As a Hyaluronic Acid derivative, it has a well-tolerated profile and suits most skin types.

Polygonum Cuspidatum Root Extract comes from the Japanese Knotweed plant native to Japan, Korea, and China.

This plant contains anti-inflammatory and antioxidant properties. It contains high amounts of resveratrol, a potent antioxidant.

The root of the plant has been used in traditional folk medicine throughout Asia.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

This is a botanical extract from the rosemary plant (the same one you cook with). In skincare, it mostly works as a skin conditioning agent.

Its activity comes from a handful of polyphenols, carnosic acid, carnosol, and rosmarinic acid. Almost 90% of the antioxidant activity of this ingredient can be attributed to canosol and carnosic acid.

These compounds protect your skin two ways:

1) They fight off free radicals, or the unstable molecules from things like sun and pollution that age and damage skin. 2) They help calm inflammation by switching off the chemical signals that tell skin to get red and irritated.

Lab studies also suggest that rosmarinic acid may help protect collagen and slow sugar-related damage to it.

The Cosmetic Ingredient Review has concluded rosemary-derived ingredients to be safe when formulated to be non-sensitizing.

Rosemary can occasionally cause allergic contact dermatitis (due to carnosol), so be sure to patch test if you have reactive or fragrance-sensitive skin.

Sclerotium Gum is a natural sugar-based fiber made by fermenting a fungus called Sclerotium rolfsii. It's often used as the plant-friendly alternative for synthetic thickeners like carbomer.

In skincare, it works as a thickener, gel former, and stabilizer that keeps heavy ingredients suspended so a product does not separate.

It is non-ionic and forms a triple helix in solution. This is just a fancy way of saying it builds a smooth, cushiony, and non-sticky gel that feels silkier than many other gums.

Another perk of this ingredient is that it is very sturdy and holds up across a wide pH range (~2-11). It's also good at resisting heat and hydrolysis.

Since it holds water at the skin surface, it can provide some light hydration as well.

Typical use levels are around 0.25-2%; formulators usually use 0.2-0.5% to thicken lotions and up to 2% for a firmer gel base.

This ingredient has been found safe in cosmetics with no meaningful evidence of skin sensitization.

Scutellaria Baicalensis Root Extract comes from the Baikal skullcap or Chinese skullcap plant. This plant is native to Northeast Asia and can be found in China, Mongolia, Korea, and Siberia.

In cosmetics, Scutellaria Baicalensis Root Extract provides antioxidant and anti-inflammatory benefits. This is due to the flavonoid composition of Scutellaria Baicalensis Root Extract.

In Chinese traditional folk medicine, Scutellaria Baicalensis Root Extract is used to help treat lung issues and hypertension.

Sodium Acetylated Hyaluronate is a type of Hyaluronic Acid.

Hyaluronic Acids help moisturize, soothe, and protect the skin.

Read about common types of Hyaluronic Acid here:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.

A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.

A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.

More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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