AXIS - Y Vegan Collagen Eye Serum Versus BOH Bio Heal Probioderm 3D Lifting Eye & Wrinkle Cream

AXIS - Y Vegan Collagen Eye Serum Versus BOH Bio Heal Probioderm 3D Lifting Eye & Wrinkle Cream

This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Pentapeptide-4 to soften the look of wrinkles.

This anti-aging eye moisturizer is formulated around Lactobacillus Ferment Lysate and Lactobacillus Ferment to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Methylpropanediol

Glycerin

1,2-Hexanediol

Niacinamide

Adenosine

Collagen

Sodium Hyaluronate

Hydrolyzed Hyaluronic Acid

Sodium Acetylated Hyaluronate

Tripeptide-1

Palmitoyl Pentapeptide-4

Hexapeptide-9

Acetyl Hexapeptide-8

Copper Tripeptide-1

Pyrus Malus Fruit Extract

Prunus Mume Fruit Extract

Vitis Vinifera Fruit Extract

Helianthus Annuus Seed Oil

Simmondsia Chinensis Seed Oil

Limnanthes Alba Seed Oil

Carica Papaya Fruit Extract

Centella Asiatica Extract

Ficus Carica Fruit Extract

Ulmus Davidiana Root Extract

Amaranthus Caudatus Seed Extract

Ceramide NP

Hydrogenated Lecithin

Leuconostoc/Radish Root Ferment Filtrate

Butylene Glycol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

C13-14 Alkane

Sodium Acrylic Acid/Ma Copolymer

C15-23 Alkane

Ethylhexylglycerin

Decyl Glucoside

Caprylyl Glycol

Polyglyceryl-10 Stearate

Tocopherol

Water, Methylpropanediol, Glycerin, 1,2-Hexanediol, Niacinamide, Adenosine, Collagen, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Tripeptide-1, Palmitoyl Pentapeptide-4, Hexapeptide-9, Acetyl Hexapeptide-8, Copper Tripeptide-1, Pyrus Malus Fruit Extract, Prunus Mume Fruit Extract, Vitis Vinifera Fruit Extract, Helianthus Annuus Seed Oil, Simmondsia Chinensis Seed Oil, Limnanthes Alba Seed Oil, Carica Papaya Fruit Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Ceramide NP, Hydrogenated Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, C13-14 Alkane, Sodium Acrylic Acid/Ma Copolymer, C15-23 Alkane, Ethylhexylglycerin, Decyl Glucoside, Caprylyl Glycol, Polyglyceryl-10 Stearate, Tocopherol

Lactobacillus Ferment Lysate

Caprylic/Capric Triglyceride

Diisostearyl Malate

Cetearyl Alcohol

Cetearyl Olivate

Lactobacillus Ferment

Fructooligosaccharides

Fructan

Inulin

Panthenol

Betaine

Beta-Glucan

Saponins

Soluble Proteoglycan

Acetyl Tetrapeptide-5

Nonapeptide-1

Acetyl Tetrapeptide-9

Acetyl Hexapeptide-1

Palmitoyl Tripeptide-8

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-5

Palmitoyl Hexapeptide-12

Pentapeptide-3

Oligopeptide-2

Laminaria Japonica Extract

Eclipta Prostrata Leaf Extract

Malt Extract

Elaeis Guineensis Oil

Polyglycerin-3

Polymethylsilsesquioxane

Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate

Sorbitan Olivate

Stearyl Dimethicone

Vinyldimethicone

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Dimethicone/Vinyl Dimethicone Crosspolymer

Hydroxyacetophenone

Octadecene

Euphorbia Cerifera Wax

Dipropylene Glycol

Polyacrylate-13

Xanthan Gum

Glyceryl Acrylate/Acrylic Acid Copolymer

Hydrogenated Polyisobutene

Sorbitan Isostearate

Polyglyceryl-10 Myristate

Disodium EDTA

Polyglyceryl-10 Laurate

Ethylhexyl Palmitate

Cyanocobalamin

Arginine

Carbomer

Maltodextrin

Propanediol

Sodium Phosphate

Algin

Biosaccharide Gum-4

Dextran

Mineral Salts

Disodium Phosphate

Parfum

Water, Lactobacillus Ferment Lysate, Glycerin, Caprylic/Capric Triglyceride, Diisostearyl Malate, Cetearyl Alcohol, Cetearyl Olivate, Lactobacillus Ferment, Fructooligosaccharides, Fructan, Inulin, Panthenol, Betaine, Beta-Glucan, Adenosine, Saponins, Soluble Proteoglycan, Acetyl Tetrapeptide-5, Nonapeptide-1, Acetyl Tetrapeptide-9, Acetyl Hexapeptide-1, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-8, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Copper Tripeptide-1, Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Palmitoyl Hexapeptide-12, Pentapeptide-3, Hexapeptide-9, Oligopeptide-2, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Malt Extract, Elaeis Guineensis Oil, Hydrogenated Lecithin, Polyglycerin-3, Polymethylsilsesquioxane, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Sorbitan Olivate, Stearyl Dimethicone, 1,2-Hexanediol, Butylene Glycol, Vinyldimethicone, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone/Vinyl Dimethicone Crosspolymer, Hydroxyacetophenone, Octadecene, Euphorbia Cerifera Wax, Dipropylene Glycol, Polyacrylate-13, Ethylhexylglycerin, Xanthan Gum, Glyceryl Acrylate/Acrylic Acid Copolymer, Hydrogenated Polyisobutene, Sorbitan Isostearate, Polyglyceryl-10 Myristate, Disodium EDTA, Polyglyceryl-10 Laurate, Ethylhexyl Palmitate, Hydrolyzed Hyaluronic Acid, Cyanocobalamin, Arginine, Carbomer, Maltodextrin, Tocopherol, Propanediol, Sodium Phosphate, Caprylyl Glycol, Algin, Biosaccharide Gum-4, Dextran, Mineral Salts, Disodium Phosphate, Parfum

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hexapeptide-9 is a signaling peptide that is made to mimic a fragment found naturally in collagen IV and XVII.

It is classified as a matrikine peptide and works by telling your skin cells (especially fibroblasts) to ramp up collagen and hyaluronic acid production.

In-vitro studies show it can enhance epidermal regeneration, boost synthesis of collagen types I, III, and IV, and improved markers of skin differentiation.

Think of skin differentiation like this: your skin cells are born at the bottom and slowly travel up to the surface as they "grow up". As they move up, they start producing specific proteins that make your skin do its job well. Two of these proteins are keratin (it makes your skin tough) and filaggrin (it breaks apart into tiny molecules to keep your skin hydrated). So Hexapeptide-9 has shown to help skin cells grow up properly and make stronger, more hydrated skin.

A manufacturer also reports increased collagen production by 117% and hyaluronic acid production by 267%.

Just know much of the published data comes from manufacturer-sponsored studies. There is a recent clinical trial showing promising anti-aging results but the evidence base is still growing.

Generally, this ingredient is well-tolerated and there's no harm in using it as a supportive ingredient in your routine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

You might know this ingredient as Matrixyl. It is a synthetic peptide made up of five amino acids attached to a palmitic acid, a fatty acid that helps it absorb into skin more easily.

As a signal peptide, Matrixyl acts like a little messenger. Once it reaches your skin cells, it tells them to ramp up production of collagen, elastin, and other proteins that keep skin looking firm and smooth.

A 12 week clinical study found that a moisturizer containing just 3 ppm of Matrixyl led to a significant improvement in fine-lines and wrinkles. Another study showed an 18% reduction in wrinkle depth, 37% reduction in wrinkle thickness, and a 21% improvement in skin firmness after just 28 days of twice-daily use.

The coolest part is that it works at incredibly low concentrations (like 0.0003%) and it plays well with other actives.

The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization.

Fun fact: Matrixyl was originally developed by French company Sederma and Procter & Gamble.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Tripeptide-1, also known as GHK), is a small, three-amino-acid peptide made up of glycine, histidine, and lysine.

This ingredient is a signal peptide and tell your skin to start producing fresh collagen, elastin, and other key structural proteins. This helps maintain firmness and reduces the look of fine-lines/wrinkles.

GHK is also unique because is also acts as a carrier peptide. It binds to and transports copper ions (forming the complex GHK-Cu). This form has been studied for decades and is known to stimulate wound healing, boost antioxidant defenses, and promote collagen/elastin synthesis.

In-vitro studies show both GHK and GHK-CU increase fibroblast activity that enhances the production of collagen, elastin, fibronectin, and other extracellular matrix components.

Both of these compounds also help balance enzymes that control collagen breakdown.

Human studies (in-vivo) using GHK-Cu creams have reported visible improvements to skin density, elasticity, and wrinkle depth after several weeks of use.

A small clinical study also found topical collagen tripeptide improved wrinkle appearance and skin elasticity in women after four weeks.

While these results are promising, most research is based on GHK-Cu or its derivatives rather than Tripeptide-1 alone (Palmitoyl Tripeptide-1 is a famous derivative of GHK). However, the consensus still supports GHK as a potent skin-signaling molecule that can encourage regeneration and maintain youthful looking skin.

Fun fact: GHK is a naturally occurring fragment of type 1 collagen that can be found in human plasma, saliva, and urine.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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