Collagen supplements: Benefits, safety, and effects

The side effects of collagen supplements may include heaviness in the stomach, mild diarrhea, or skin rashes. However, many people take collagen without experiencing any adverse effects.

A 2022 review notes that much of the previous research on collagen supplements has reported no side effects. Most of the studies occurred over 12 to 24 weeks, though, so this may not apply to long-term use.

More research is necessary on the long-term effects of taking collagen over a person’s life, particularly as people age.

Collagen is a type of protein that the body makes naturally. It helps maintain skin structure and elasticity and plays a role in joint and bone health. Over time, the body makes less collagen, contributing to a loss of skin elasticity, joint pain, and weaker bones.

People often take collagen to reduce these symptoms. There is mixed evidence on whether collagen supplements work, but some research has had promising results, showing an improvement in skin elasticity and toughness, and a reduction in wrinkles.

However, collagen may not be suitable for everyone. Allergies to collagen are rare, but they are possible. Additionally, although there are no well-known drug interactions for collagen, there may be contraindications that researchers are unaware of.

Some people with histamine intolerance anecdotally report having issues with collagen, while others say that it affects their sleep or mood. Research is necessary to investigate this.

If a person takes collagen and begins experiencing any new symptoms, they should stop taking it and speak with a doctor. Seek immediate help if any of the following appear:

• a rash that spreads rapidly
• swelling of the mouth or airways
• difficulty breathing
• fast, shallow breathing
• a rapid or weak pulse
• an inability to keep food or water down

Vegetarians and vegans should be aware that most collagen is from animal sources, such as cows and fish. Some vegan collagen supplements are available, but there is less research on plant-derived proteins, according to a 2020 review.