COSRX Advanced Snail 92 All In One Cream Versus MediCube PDRN Pink Collagen Capsule Cream

COSRX Advanced Snail 92 All In One Cream Versus MediCube PDRN Pink Collagen Capsule Cream

This barrier-repair moisturizer is formulated around Snail Secretion Filtrate and Allantoin to strengthen the skin barrier and hydrate skin.

This anti-aging moisturizer is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Snail Secretion Filtrate

Betaine

Caprylic/Capric Triglyceride

Butylene Glycol

Cetearyl Olivate

Sorbitan Olivate

Cetearyl Alcohol

Carbomer

Ethyl Hexanediol

Phenoxyethanol

Arginine

Dimethicone

Sodium Polyacrylate

Sodium Hyaluronate

Allantoin

Palmitic Acid

Panthenol

Xanthan Gum

Stearic Acid

Adenosine

Water

Myristic Acid

Snail Secretion Filtrate, Betaine, Caprylic/Capric Triglyceride, Butylene Glycol, Cetearyl Olivate, Sorbitan Olivate, Cetearyl Alcohol, Carbomer, Ethyl Hexanediol, Phenoxyethanol, Arginine, Dimethicone, Sodium Polyacrylate, Sodium Hyaluronate, Allantoin, Palmitic Acid, Panthenol, Xanthan Gum, Stearic Acid, Adenosine, Water, Myristic Acid

Glycerin

Niacinamide

Methylpropanediol

Propanediol

1,2-Hexanediol

Dipropylene Glycol

Glycereth-26

Ethylhexyl Palmitate

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Simethicone

Eclipta Prostrata Extract

Ethylhexylglycerin

Polyacrylate-13

Sodium DNA

Disodium EDTA

Melia Azadirachta Leaf Extract

Polyisobutene

Hydrolyzed Sclerotium Gum

Glyceryl Stearate

Moringa Oleifera Seed Oil

Polysorbate 20

Sorbitan Isostearate

Glutathione

Octyldodecanol

Hydroxypropyltrimonium Hyaluronate

Salmon Egg Extract

Hydrogenated Lecithin

Ceramide NP

Cyanocobalamin

Thioctic Acid

Hydrolyzed Hyaluronic Acid

Hydrolyzed Collagen Extract

Sodium Acetylated Hyaluronate

Acetyl Hexapeptide-8

Copper Tripeptide-1

Hyaluronic Acid

Caprylyl Glycol

Palmitoyl Pentapeptide-4

Hydrolyzed Sodium Hyaluronate

Palmitoyl Hexapeptide-12

Sodium Hyaluronate Crosspolymer

Potassium Hyaluronate

Water, Glycerin, Niacinamide, Methylpropanediol, Propanediol, 1,2-Hexanediol, Dipropylene Glycol, Caprylic/Capric Triglyceride, Glycereth-26, Arginine, Butylene Glycol, Ethylhexyl Palmitate, Cetearyl Alcohol, Carbomer, Cetearyl Olivate, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Simethicone, Eclipta Prostrata Extract, Ethylhexylglycerin, Adenosine, Polyacrylate-13, Sodium DNA, Disodium EDTA, Melia Azadirachta Leaf Extract, Polyisobutene, Hydrolyzed Sclerotium Gum, Glyceryl Stearate, Moringa Oleifera Seed Oil, Polysorbate 20, Sorbitan Isostearate, Sodium Hyaluronate, Glutathione, Octyldodecanol, Hydroxypropyltrimonium Hyaluronate, Salmon Egg Extract, Hydrogenated Lecithin, Ceramide NP, Cyanocobalamin, Thioctic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Collagen Extract, Sodium Acetylated Hyaluronate, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Pentapeptide-4, Hydrolyzed Sodium Hyaluronate, Palmitoyl Hexapeptide-12, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.

You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.

These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.

This ingredient is well-tolerated and has no significant sensitization data.

Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.

This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.

According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.

Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.

Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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