Derma E Advanced Peptides And Collagen Moisturizer Versus DRMTLGY Needle-Less Serum
Derma E Advanced Peptides And Collagen Moisturizer Versus DRMTLGY Needle-Less Serum This anti-aging moisturizer is formulated around Palmitoyl Tripeptide-38 and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture. This anti-aging serum
Derma E Advanced Peptides And Collagen Moisturizer Versus DRMTLGY Needle-Less Serum
This anti-aging moisturizer is formulated around Palmitoyl Tripeptide-38 and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.
This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Macadamia Ternifolia Seed Oil
Caprylic/Capric Triglyceride
Stearic Acid
Cetyl Alcohol
Glyceryl Stearate Citrate
Dimethicone
Hydroxypropyl Cyclodextrin
Palmitoyl Tripeptide-38
Acetyl Hexapeptide-8
Panthenol
Pinus Pinaster Bark Extract
Glyceryl Stearate Se
Acacia Seyal Gum Extract
Tocopheryl Acetate
Ascorbyl Palmitate
Hamamelis Virginiana Bark/Leaf Extract
Aesculus Hippocastanum Seed Extract
Camellia Sinensis Leaf Extract
Chamomilla Recutita Flower
Simmondsia Chinensis Seed Oil
Allantoin
Xanthan Gum
Potassium Sorbate
Sodium Hydroxide
Phenoxyethanol
Ethylhexylglycerin
Parfum
Water, Glycerin, Macadamia Ternifolia Seed Oil, Caprylic/Capric Triglyceride, Stearic Acid, Cetyl Alcohol, Glyceryl Stearate Citrate, Dimethicone, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Acetyl Hexapeptide-8, Panthenol, Pinus Pinaster Bark Extract, Glyceryl Stearate Se, Acacia Seyal Gum Extract, Tocopheryl Acetate, Ascorbyl Palmitate, Hamamelis Virginiana Bark/Leaf Extract, Aesculus Hippocastanum Seed Extract, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower, Simmondsia Chinensis Seed Oil, Allantoin, Xanthan Gum, Potassium Sorbate, Sodium Hydroxide, Phenoxyethanol, Ethylhexylglycerin, Parfum
Sodium Chondroitin Sulfate
Sodium Hyaluronate
Pisum Sativum Extract
Bambusa Vulgaris Leaf/Stem Extract
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Ceramide EOP
Glucosamine Hcl
Glycosaminoglycans
Ceramide NP
Palmitoyl Tripeptide-5
Ceramide AP
Phytosphingosine
Cholesterol
Niacinamide
Sodium Lauroyl Lactylate
Methylglucoside Phosphate
Copper Lysinate/Prolinate
Polysorbate 20
Disodium EDTA
Butylene Glycol
Carbomer
Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum Extract, Bambusa Vulgaris Leaf/Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Glucosamine Hcl, Glycosaminoglycans, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Panthenol, Tocopheryl Acetate, Phenoxyethanol, Polysorbate 20, Ethylhexylglycerin, Disodium EDTA, Butylene Glycol, Carbomer, Xanthan Gum
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.