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Dr. Dennis Gross Skincare C+ Collagen Brighten & Firm Vitamin C Serum Versus Timeless Skin Care 10% Vitamin C + E Ferulic Acid Serum

Dr. Dennis Gross Skincare C+ Collagen Brighten & Firm Vitamin C Serum Versus Timeless Skin Care 10% Vitamin C + E Ferulic Acid Serum This brightening serum is formulated around 3-O-Ethyl Ascorbic Acid and Niacinamide to brighten dull-looking skin and soften th

By Collagen & Peptide Nutrition Editorial TeamPublished

Dr. Dennis Gross Skincare C+ Collagen Brighten & Firm Vitamin C Serum Versus Timeless Skin Care 10% Vitamin C + E Ferulic Acid Serum

This brightening serum is formulated around 3-O-Ethyl Ascorbic Acid and Niacinamide to brighten dull-looking skin and soften the look of wrinkles.

This brightening serum is formulated around Ascorbic Acid and Tocopherol to brighten dull-looking skin and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

3-O-Ethyl Ascorbic Acid

Niacinamide

Glycereth-7 Triacetate

Lactic Acid

Sd Alcohol 40-B

Hydroxyethylcellulose

Dimethyl Isosorbide

Ascorbic Acid

Collagen Amino Acids

Superoxide Dismutase

Glycine

Carnitine Hcl

Ubiquinone

Hexylresorcinol

Emblica Officinalis Fruit Extract

Hydrolyzed Soy Protein

Tetrahexyldecyl Ascorbate

Isoquercetin

Mandelic Acid

Pueraria Lobata Root Extract

Curcuma Longa Root Extract

Phytic Acid

Citric Acid

Tetrasodium EDTA

Sodium Citrate

Butylene Glycol

Xanthan Gum

Polysorbate 20

T-Butyl Alcohol

Sodium Hydroxide

Polysorbate 80

Denatonium Benzoate

Benzyl Alcohol

Phenoxyethanol

Sodium Benzoate

Potassium Sorbate

Water, Glycerin, 3-O-Ethyl Ascorbic Acid, Niacinamide, Glycereth-7 Triacetate, Lactic Acid, Sd Alcohol 40-B, Hydroxyethylcellulose, Dimethyl Isosorbide, Ascorbic Acid, Collagen Amino Acids, Superoxide Dismutase, Glycine, Carnitine Hcl, Ubiquinone, Hexylresorcinol, Emblica Officinalis Fruit Extract, Hydrolyzed Soy Protein, Tetrahexyldecyl Ascorbate, Isoquercetin, Mandelic Acid, Pueraria Lobata Root Extract, Curcuma Longa Root Extract, Phytic Acid, Citric Acid, Tetrasodium EDTA, Sodium Citrate, Butylene Glycol, Xanthan Gum, Polysorbate 20, T-Butyl Alcohol, Sodium Hydroxide, Polysorbate 80, Denatonium Benzoate, Benzyl Alcohol, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate

Ethoxydiglycol

Propylene Glycol

Tocopherol

Panthenol

Ferulic Acid

Sodium Hyaluronate

Dehydroacetic Acid

Water, Ethoxydiglycol, Ascorbic Acid, Propylene Glycol, Tocopherol, Polysorbate 80, Panthenol, Ferulic Acid, Sodium Hyaluronate, Benzyl Alcohol, Dehydroacetic Acid

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Ascorbic Acid is is pure Vitamin C and is the biologically active form used directly by skin.

Not only is vitamin C great for your overall health and immune system, but it also has plenty of benefits for your skin. It is best supported by academic literature for:

Topical vitamin C has been shown to help neutralize oxidative stress from UV and pollution, helping to improve photoaging and hyperpigmentation when used consistently.

One clinical study found that using 5% topical vitamin C for six months improved signs of photodamaged skin, both on the surface and in the deeper structural layers of the skin.

While vitamin C doesn’t replace sunscreen, studies show it can boost photoprotection when combined with Vitamin E and ferulic acid. These two ingredients help improve stability and protective effects.

The big downside of this ingredient is formulation difficulty. Vitamin C is prone to oxidation and doesn't penetrate the skin unless formulated correctly. Research found that vitamin C absorbs into the skin best at a low pH (< 3.5) with about 20% being the upper limit for effective absorption.

Skin levels can saturate after repeated application; this means your skin won’t keep absorbing more once it’s full of vitamin C. This is why more isn’t always better with vitamin C and why very high concentrations don’t necessarily give extra benefits.

Ascorbic acid generally works well with many skincare ingredients but can be irritating when combined with other active ingredients. Strong oxidizing acne treatments like benzoyl peroxide can reduce the effectiveness of vitamin C if they are used at the same time; they are often recommended for use at different times of day.

Read more about other types of Vitamin C:

Foods rich with vitamin C include oranges, strawberries, broccoli, bell peppers, and more. When consuming Vitamin C, your skin receives a portion of the nutrients.

Benzyl Alcohol is an aromatic alcohol with several roles: it's a preservative, solvent, and mild fragrance component with a floral scent.

This ingredient has been deemed safe for use in cosmetic formulations at concentrations up to 5%, and up to 10% in hair dyes. You'll typically see 0.5-2% in most rinse-off or leave-on products.

As a preservative, it works by disrupting the membrane of microbial proteins. This helps keep bacteria and fungi from growing in your products.

The sensitization picture is actually quite assuring as well:of nearly 71,000 patients patch tested with benzyl alcohol, only 0.21% showed a positive reaction with most of them being weakly positive.

This led researchers to conclude that benzyl alcohol cannot be regarded as a significant contact allergen.

It is worth noting this ingredient is classified as one of the EU's regulated fragrance allergens and restricted to 1% in finished products.

Labels must also declare it in concentrations above 0.001% in leave-on products and 0.01% in rinse-off products.

At concentrations around 5%, localized redness and itching can appear as a direct irritant response and not as a true allergic reaction.

Polysorbate 80 is a synthetic surfactant and emulsifier derived from sorbitol and oleic acid.

It reduces the surface tension between oil and water phases to help them stay mixed and stable in a formulation. In other words, it prevents your formulas from separating into an oily mess.

The CIR Expert Panel has evaluated the scientific data and found this ingredient to be safe, non-irritating, and non-sensitizing at concentrations up to 5% (it's even approved by the FDA as an OTC eye drop ingredient).

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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SUPPLEMENTAL FIELD FILE

Notes to carry forward.

Source-derived references linked through this guide’s public topic markers.

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REFERENCE CARDS

Ingredients, lists & structured values

INGREDIENT LIST

Ingredients Explained

  • These ingredients are found in both products.
  • Ingredients higher up in an ingredient list are typically present in a larger amount.
  • Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  • Topically, glycerin does several things at once:
  • Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  • Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  • This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  • Just know very high concentrations (>40%) can feel tacky in low humidity.
  • Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  • Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
  • It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
  • On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
  • Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
  • You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
  • Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
  • Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
  • Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
  • Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
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Products & side-by-side records

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