MEDI-PEEL Aesthe Derma Red Marine Collagen Toner Versus MEDI-PEEL Derma Maison Hyalcica Moisture Toner

MEDI-PEEL Aesthe Derma Red Marine Collagen Toner Versus MEDI-PEEL Derma Maison Hyalcica Moisture Toner

This anti-aging toner is formulated around Niacinamide and Copper Tripeptide-1 to soften the look of wrinkles.

This hydrating toner is formulated around Panthenol and Centella Asiatica Extract to hydrate skin and calm redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dipropylene Glycol

Niacinamide

1,2-Hexanediol

Hydrolyzed Collagen

Sodium Hyaluronate

Lactobacillus Ferment

Butylene Glycol

Xylitylglucoside

Anhydroxylitol

Xylitol

Pyrus Communis Fruit Extract

Rosa Damascena Flower Water

Iris Florentina Root Extract

Cucumis Melo Fruit Extract

Hedera Helix Leaf/Stem Extract

Copper Tripeptide-1

Acetyl Hexapeptide-8

Palmitoyl Pentapeptide-4

Dipeptide-2

Acetyl Octapeptide-3

Acetyl Tetrapeptide-5

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Glycyrrhiza Glabra Root Extract

Cimicifuga Dahurica Root Extract

Polygonum Multiflorum Root Extract

Sesamum Indicum Seed Extract

Phellinus Linteus Extract

Angelica Gigas Root Extract

Morus Alba Bark Extract

Paeonia Albiflora Root Extract

Sophora Angustifolia Root Extract

Scutellaria Baicalensis Root Extract

Diospyros Kaki Leaf Extract

Vitis Vinifera Fruit Extract

Coffea Arabica Seed Extract

Carthamus Tinctorius Flower Extract

Polygonum Cuspidatum Root Extract

Camellia Sinensis Leaf Extract

Castanea Crenata Shell Extract

Zanthoxylum Piperitum Fruit Extract

Lysine

Histidine

Arginine

Aspartic Acid

Threonine

Serine

Glutamic Acid

Proline

Glycine

Alanine

Valine

Methionine

Isoleucine

Leucine

Tyrosine

Phenylalanine

Cysteine

Adenosine

Panthenol

Ceramide NP

Hydrolyzed Elastin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Disodium EDTA

Betaine

Caramel

Polyglyceryl-10 Myristate

Ethylhexylglycerin

Hydroxyacetophenone

Caprylyl Glycol

Dipotassium Glycyrrhizate

Tromethamine

Water, Glycerin, Dipropylene Glycol, Niacinamide, 1,2-Hexanediol, Hydrolyzed Collagen, Sodium Hyaluronate, Lactobacillus Ferment, Butylene Glycol, Xylitylglucoside, Anhydroxylitol, Xylitol, Pyrus Communis Fruit Extract, Rosa Damascena Flower Water, Iris Florentina Root Extract, Cucumis Melo Fruit Extract, Hedera Helix Leaf/Stem Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Octapeptide-3, Acetyl Tetrapeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Glycyrrhiza Glabra Root Extract, Cimicifuga Dahurica Root Extract, Polygonum Multiflorum Root Extract, Sesamum Indicum Seed Extract, Phellinus Linteus Extract, Angelica Gigas Root Extract, Morus Alba Bark Extract, Paeonia Albiflora Root Extract, Sophora Angustifolia Root Extract, Scutellaria Baicalensis Root Extract, Diospyros Kaki Leaf Extract, Vitis Vinifera Fruit Extract, Coffea Arabica Seed Extract, Carthamus Tinctorius Flower Extract, Polygonum Cuspidatum Root Extract, Camellia Sinensis Leaf Extract, Castanea Crenata Shell Extract, Zanthoxylum Piperitum Fruit Extract, Lysine, Histidine, Arginine, Aspartic Acid, Threonine, Serine, Glutamic Acid, Proline, Glycine, Alanine, Valine, Methionine, Isoleucine, Leucine, Tyrosine, Phenylalanine, Cysteine, Adenosine, Panthenol, Ceramide NP, Hydrolyzed Elastin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium EDTA, Betaine, Caramel, Polyglyceryl-10 Myristate, Ethylhexylglycerin, Hydroxyacetophenone, Caprylyl Glycol, Dipotassium Glycyrrhizate, Tromethamine

Glycereth-26

Carbomer

C12-14 Pareth-12

Allantoin

Gluconolactone

Propanediol

Hydrogenated Lecithin

Ozothamnus Diosmifolius Extract

Centella Asiatica Extract

Sodium Hyaluronate Crosspolymer

Ficus Carica Fruit Extract

Hydrolyzed Glycosaminoglycans

Centella Asiatica Root Extract

Centella Asiatica Flower/Leaf/Stem Extract

Centella Asiatica Leaf Extract

Moringa Oleifera Seed Extract

Benzyl Glycol

Hydrolyzed Hyaluronic Acid

Sodium Citrate

Bourbon Extract

Phragmites Karka Extract

Citric Acid

Sodium Benzoate

Polysorbate 20

Lecithin

Madecassoside

Asiaticoside

Sodium Acetylated Hyaluronate

Hyaluronic Acid

Ornithine

Taurine

CI 42090

Parfum

Water, Butylene Glycol, Glycerin, Glycereth-26, 1,2-Hexanediol, Arginine, Carbomer, Betaine, Panthenol, Ethylhexylglycerin, Disodium EDTA, C12-14 Pareth-12, Allantoin, Gluconolactone, Propanediol, Hydrogenated Lecithin, Ozothamnus Diosmifolius Extract, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ficus Carica Fruit Extract, Hydrolyzed Glycosaminoglycans, Sodium Hyaluronate, Centella Asiatica Root Extract, Centella Asiatica Flower/Leaf/Stem Extract, Centella Asiatica Leaf Extract, Moringa Oleifera Seed Extract, Benzyl Glycol, Ceramide NP, Hydrolyzed Hyaluronic Acid, Sodium Citrate, Bourbon Extract, Phragmites Karka Extract, Citric Acid, Sodium Benzoate, Polysorbate 20, Lecithin, Madecassoside, Asiaticoside, Sodium Acetylated Hyaluronate, Hyaluronic Acid, Palmitoyl Pentapeptide-4, Phenylalanine, Proline, Serine, Valine, Ornithine, Taurine, Aspartic Acid, Alanine, Methionine, Leucine, Isoleucine, Glutamic Acid, Glycine, Histidine, CI 42090, Parfum

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Aspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.

Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.

Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.

Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.

Some studies suggest betaine may support making skin tone more even.

Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.

Betaine is also known as trimethylglycine.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glutamic Acid is an amino acid that is found in all living organisms. Our bodies use this to help nerve cells in the brain communicate with other cells.

In cosmetics, glutamic acid is a famous humectant. It draws water from the air to your skin, keeping your skin hydrated (like hyaluronic acid).

An in-vitro study from 2024 found glutamic acid to play a role in inhibiting inflammation and thus a potential skin-soothing ingredient.

Other studies show it to be have potential wound healing, skin barrier repair, and hair growth properties.

Glutamic acid has poor solubility in water and other solvents.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.

Histidine is a semi-essential amino acid used by our bodies to create protein. It has humectant and skin conditioning properties.

Our bodies use histidine to create filaggrin - filaggrin is a structural protein that the skin uses in maintaining skin barrier.

One study found histidine and carnosine to be a dynamic duo for your skin:

Oral histidine has also been found to help with filaggrin-deficit skin disorders such as atopic dermatitis.

Why is it considered a semi-essential amino acid? This is because adults are able to create it but children must get it from their diet.

Isoleucine is an amino acid that helps reinforce our skin barrier. This amino acid plays a role in creating protein for the body.

Fun fact: Isoleucine is found in meat, fish, dairy, legumes, and nuts.

Leucine is a small amino acid and one of the building blocks your body uses to make proteins.

It's also naturally found in your skin as part of your Natural Moisturizing Factor (NMF). Your NMF is a mix of water-binding molecules that keeps the outer skin layer hydrated and flexible.

In skincare, it's mainly used as a skin conditioning ingredient that helps reinforce the same moisture-retention function.

You'll usually see it used at low percentages (generally under 5%) which is in line with how amino acids are used in cosmetics.

Methionine is a natural amino acid your skin already uses to make proteins and gluthatione (one of the body's key defense molecules against environmental stress like sun + pollution).

Its sulfur content makes it especially reactive with the free radicals that damage skin, giving it genuine antioxidant properties.

Usage percentages are usually under 1%, and usually as part of an amino acid mix designed to mimic what's naturally in skin.

One study used a combination of essential amino acids at 0.2% with supplemental methionine added and found significantly boosted collagen production in human skin.

Cosmetic industry reviewers have looked closely at methionine and other amino acids and found them well tolerated. Methionine is actually used as a "negative control" in lab tests designed to spot irritating ingredients because it doesn't cause a reaction.

You might know this ingredient as Matrixyl. It is a synthetic peptide made up of five amino acids attached to a palmitic acid, a fatty acid that helps it absorb into skin more easily.

As a signal peptide, Matrixyl acts like a little messenger. Once it reaches your skin cells, it tells them to ramp up production of collagen, elastin, and other proteins that keep skin looking firm and smooth.

A 12 week clinical study found that a moisturizer containing just 3 ppm of Matrixyl led to a significant improvement in fine-lines and wrinkles. Another study showed an 18% reduction in wrinkle depth, 37% reduction in wrinkle thickness, and a 21% improvement in skin firmness after just 28 days of twice-daily use.

The coolest part is that it works at incredibly low concentrations (like 0.0003%) and it plays well with other actives.

The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization.

Fun fact: Matrixyl was originally developed by French company Sederma and Procter & Gamble.

Read more about other common types of peptides here:

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Phenylalanine is an amino acid. It is a skin soothing and hydrating ingredient. Amino acids play a crucial role in wound healing and skin hydration.

This ingredient is also used to help even out skin tone due to its ability to disrupt the melanin production process.

Two structures of phenylalanine exist: L-phenylalanine and D-phenylalanine. L-phenylalanine is essential, this means our bodies cannot produce it naturally and we must get it from foods. Our bodies convert D-phenylalanine to neurotransmitters, and D-phenylalanine is found in our bodies naturally.

Some foods that contain L-phenylalanine include eggs, soybeans, beef, milk.

Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.

It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.

Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.

Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.

Serine is a non-essential amino acid (your body makes it on its own!). It is a major player in your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Serine is one of your NMF's most abundant components that works as a skin-identical humectant. Its hydroxyl group grabs onto water molecules to boost hydration without any heaviness or occlusion.

Research on a hydrogel with serine confirmed this serine got delivered to your stratum corneum and demonstrated enhanced skin moisturization.

Interestingly serine also helps your skin produce filaggrin, a protein that keeps your skin barrier strong and used to create collagen.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Valine is one of the essential amino acids (meaning your body can't make it on its own and has to get it from food).

In skincare, it's usually synthetically-made or pulled from plant proteins like soy.

It's one of the small building blocks that make up your skin's natural moisturizing factor (NMF), or the built-in system that helps skin hold onto water. So its main job in a formula is to give the skin gentle hydration and help it feel more comfortable.

Typical amounts are very tiny: roughly 0.00004%-0.5% in leave on products and up to 1% in rinse-off ones.

The Cosmetic Ingredient Review panel has looked at this ingredient and found no evidence of it being a skin irritant or allergen at cosmetic levels.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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