MEDI-PEEL Aesthe Derma Red Marine Collagen Toner Versus MEDI-PEEL Red Lacto First Collagen Essence

MEDI-PEEL Aesthe Derma Red Marine Collagen Toner Versus MEDI-PEEL Red Lacto First Collagen Essence

This anti-aging toner is formulated around Niacinamide and Copper Tripeptide-1 to soften the look of wrinkles.

This anti-aging essence is formulated around Niacinamide and Lactobacillus Ferment to soften the look of wrinkles and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dipropylene Glycol

Niacinamide

1,2-Hexanediol

Hydrolyzed Collagen

Sodium Hyaluronate

Lactobacillus Ferment

Butylene Glycol

Xylitylglucoside

Anhydroxylitol

Xylitol

Pyrus Communis Fruit Extract

Rosa Damascena Flower Water

Iris Florentina Root Extract

Cucumis Melo Fruit Extract

Hedera Helix Leaf/Stem Extract

Copper Tripeptide-1

Acetyl Hexapeptide-8

Palmitoyl Pentapeptide-4

Dipeptide-2

Acetyl Octapeptide-3

Acetyl Tetrapeptide-5

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Glycyrrhiza Glabra Root Extract

Cimicifuga Dahurica Root Extract

Polygonum Multiflorum Root Extract

Sesamum Indicum Seed Extract

Phellinus Linteus Extract

Angelica Gigas Root Extract

Morus Alba Bark Extract

Paeonia Albiflora Root Extract

Sophora Angustifolia Root Extract

Scutellaria Baicalensis Root Extract

Diospyros Kaki Leaf Extract

Vitis Vinifera Fruit Extract

Coffea Arabica Seed Extract

Carthamus Tinctorius Flower Extract

Polygonum Cuspidatum Root Extract

Camellia Sinensis Leaf Extract

Castanea Crenata Shell Extract

Zanthoxylum Piperitum Fruit Extract

Lysine

Histidine

Arginine

Aspartic Acid

Threonine

Serine

Glutamic Acid

Proline

Glycine

Alanine

Valine

Methionine

Isoleucine

Leucine

Tyrosine

Phenylalanine

Cysteine

Adenosine

Panthenol

Ceramide NP

Hydrolyzed Elastin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Disodium EDTA

Betaine

Caramel

Polyglyceryl-10 Myristate

Ethylhexylglycerin

Hydroxyacetophenone

Caprylyl Glycol

Dipotassium Glycyrrhizate

Tromethamine

Water, Glycerin, Dipropylene Glycol, Niacinamide, 1,2-Hexanediol, Hydrolyzed Collagen, Sodium Hyaluronate, Lactobacillus Ferment, Butylene Glycol, Xylitylglucoside, Anhydroxylitol, Xylitol, Pyrus Communis Fruit Extract, Rosa Damascena Flower Water, Iris Florentina Root Extract, Cucumis Melo Fruit Extract, Hedera Helix Leaf/Stem Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Dipeptide-2, Acetyl Octapeptide-3, Acetyl Tetrapeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Glycyrrhiza Glabra Root Extract, Cimicifuga Dahurica Root Extract, Polygonum Multiflorum Root Extract, Sesamum Indicum Seed Extract, Phellinus Linteus Extract, Angelica Gigas Root Extract, Morus Alba Bark Extract, Paeonia Albiflora Root Extract, Sophora Angustifolia Root Extract, Scutellaria Baicalensis Root Extract, Diospyros Kaki Leaf Extract, Vitis Vinifera Fruit Extract, Coffea Arabica Seed Extract, Carthamus Tinctorius Flower Extract, Polygonum Cuspidatum Root Extract, Camellia Sinensis Leaf Extract, Castanea Crenata Shell Extract, Zanthoxylum Piperitum Fruit Extract, Lysine, Histidine, Arginine, Aspartic Acid, Threonine, Serine, Glutamic Acid, Proline, Glycine, Alanine, Valine, Methionine, Isoleucine, Leucine, Tyrosine, Phenylalanine, Cysteine, Adenosine, Panthenol, Ceramide NP, Hydrolyzed Elastin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium EDTA, Betaine, Caramel, Polyglyceryl-10 Myristate, Ethylhexylglycerin, Hydroxyacetophenone, Caprylyl Glycol, Dipotassium Glycyrrhizate, Tromethamine

Polyglyceryl-10 Laurate

Bifida Ferment Filtrate

Lactococcus Ferment

Xanthan Gum

Citric Acid

Sodium Citrate

Mentha Arvensis Leaf Oil

Barosma Betulina Leaf Extract

Pueraria Lobata Root Extract

Ulmus Davidiana Root Extract

Oenothera Biennis Flower Extract

Pinus Palustris Leaf Extract

Hydrolyzed Hyaluronic Acid

Palmitoyl Tripeptide-5

Sodium Acetylated Hyaluronate

Water, Glycerin, Niacinamide, 1,2-Hexanediol, Betaine, Panthenol, Lactobacillus Ferment, Butylene Glycol, Polyglyceryl-10 Laurate, Bifida Ferment Filtrate, Lactococcus Ferment, Vitis Vinifera Fruit Extract, Diospyros Kaki Leaf Extract, Ethylhexylglycerin, Xanthan Gum, Polygonum Cuspidatum Root Extract, Carthamus Tinctorius Flower Extract, Coffea Arabica Seed Extract, Adenosine, Camellia Sinensis Leaf Extract, Castanea Crenata Shell Extract, Zanthoxylum Piperitum Fruit Extract, Hydrolyzed Collagen, Citric Acid, Dipotassium Glycyrrhizate, Sodium Citrate, Mentha Arvensis Leaf Oil, Barosma Betulina Leaf Extract, Rosa Damascena Flower Water, Pueraria Lobata Root Extract, Ulmus Davidiana Root Extract, Oenothera Biennis Flower Extract, Pinus Palustris Leaf Extract, Glycine, Serine, Glutamic Acid, Sodium Hyaluronate, Aspartic Acid, Leucine, Hydrolyzed Hyaluronic Acid, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Proline, Valine, Threonine, Isoleucine, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Histidine, Methionine, Cysteine, Palmitoyl Tripeptide-5, Sodium Acetylated Hyaluronate

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Aspartic Acid is an amino acid that our bodies produce naturally. It is an antioxidant.

Our body uses Aspartic Acid to help build collagen and elastin. It also plays a role in hydrating skin.

Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.

Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.

Some studies suggest betaine may support making skin tone more even.

Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.

Betaine is also known as trimethylglycine.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Camellia Sinensis Leaf Extract (tea extract) is one of the most well-researched plant extracts in skincare with an impressive resume.

Black tea, green tea, and oolong tea are all harvested from the Camellia Sinensis plant.

Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside.

In lab-grown skin models, this translated to younger, healthier, and stronger skin.

There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection.

Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums.

A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity.

The quality of the extract matters a lot here:

Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients.

Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water).

This ingredient comes from the safflower plant. It has skin conditioning properties and offers antioxidant support.

Most research for this ingredient is preclinical, meaning its done on cell cultures or animal models. These studies suggest compounds found in safflower can reduce oxidative markers and inflammatory gene expression under stress conditions.

A few studies show topical products containing safflower extracts might improve elasticity, hydration, and wrinkle appearance. However, replication and formulation-specific details are needed to confirm these effects broadly.

People with Asteraceae allergies (marigold, chamomile) may react to safflower extracts. Be sure to patch test.

Castanea Crenata Shell Extract comes from the shell of the chestnut.

Studies show chestnut shells to have antioxidant and anti-inflammatory properties.

Antioxidants protect your skin against damaging molecules. This may help reduce the signs of aging.

This ingredient is more commonly known as the coffee bean from the Coffea Arabica tree. Besides being a delicious drink, coffee beans have a ton of skin benefits.

Coffea Arabica Seed Extract (CASE) has antioxidant, anti-inflammatory, and UV-protective properties. (It should not replace your sunscreen!)

CASE contains several ingredients that protect and soothe skin. These include caffeine, polysaccharides, sucrose, lipids, minerals, and proteins.

The star ingredient in coffee is caffeine.

Caffeine helps with anti-aging, antioxidant, and photo-protection.

How? It has been shown to block collagenase (~41%), elastase (~35%), and tyrosinase (~13%).

Collagenase and elastase are enzymes that break down collagen and elastin, respectively. Tyrosinase is the enzyme that controls melanin production.

Our skin creates melanin when exposed to UV as a defense mechanism.

It should be noted most studies looked at caffeine's ability to inhibit damage from UV-B rays.

According to a manufacturer, this ingredient is often dissolved using water, glycerin, and propanediol. The caffeine content of this ingredient is about 100 ppm.

Coffea Arabica is native to Ethiopia.

Cysteine is a sulfur-containing amino acid that your body naturally makes and uses to build keratin (the protein in your hair, skin, and nails) and gluthatione (a major internal antioxidant).

In skincare, it's mostly added as an antioxidant. Some emerging research is also looking at its role in wound healing + evening out pigmentation though most of the pigmentation data comes from oral supplements rather than topical use).

Typical use concentrations for this ingredient are usually quite low (under 5% in leave-on skincare).

Safety data on cysteine specifically shows it's not a skin or eye irritant.

Diospyros Kaki Leaf Extract comes from the leaves of the Persimmon. It is native to China, India, and Korea. Persimmon leaves have anti-inflammatory and antioxidant properties.

The leaves of the persimmon tree contain triterpenoids, tannins, and ursolic acids. These components are help sooth the skin due to their antioxidant activity.

This small molecule peptide has similar benefits to Argireline, the "botox" peptide.

According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.

While this seems promising, research is lacking in proving this ingredient to be as effective as botox.

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glutamic Acid is an amino acid that is found in all living organisms. Our bodies use this to help nerve cells in the brain communicate with other cells.

In cosmetics, glutamic acid is a famous humectant. It draws water from the air to your skin, keeping your skin hydrated (like hyaluronic acid).

An in-vitro study from 2024 found glutamic acid to play a role in inhibiting inflammation and thus a potential skin-soothing ingredient.

Other studies show it to be have potential wound healing, skin barrier repair, and hair growth properties.

Glutamic acid has poor solubility in water and other solvents.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.

Histidine is a semi-essential amino acid used by our bodies to create protein. It has humectant and skin conditioning properties.

Our bodies use histidine to create filaggrin - filaggrin is a structural protein that the skin uses in maintaining skin barrier.

One study found histidine and carnosine to be a dynamic duo for your skin:

Oral histidine has also been found to help with filaggrin-deficit skin disorders such as atopic dermatitis.

Why is it considered a semi-essential amino acid? This is because adults are able to create it but children must get it from their diet.

Hydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations.

In a formula, it works mainly as a skin-conditioning and moisturizing agent.

The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper.

This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides.

It's worth being realistic here:

Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studies, not topicals).

However, recent lab and skin-model work on Hydrolyzed Fish Collagen has shown promising effects on cell viability and wound healing when used as an active.

Typical concentrations range from 0.2-2%, but the percentage can go much higher in rinse-off or hair products (sometimes even above 50%).

Clinical studies on this ingredient showed no irritation, sensitization, or phototoxicity.

If you are looking for vegan collagen, it usually goes by a different INCI name like hydrolyzed soy protein. Vegan collagen is derived from yeast, bacteria, or plant sources.

The results are varied.

A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.

However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.

Further studies are needed at this time.

Isoleucine is an amino acid that helps reinforce our skin barrier. This amino acid plays a role in creating protein for the body.

Fun fact: Isoleucine is found in meat, fish, dairy, legumes, and nuts.

This ingredient is made when the Lactobacillus bacteria (the same kind that makes yogurt and kimchi) are allowed to ferment a nutrient medium.

As it ferments, it collects lactic acid, peptides, enzymes, and other bioactive metabolites to provide:

A 2023 review noted that probiotic fermentation ingredients like this one can enhance antioxidant capacity, reduce UV-induced oxidative damage, and support barrier function.

One clinical study from the same year showed a Lactobacillus ferment lysate significantly reduced transepidermal water loss and improved skin hydration.

Another review highlighted that topical Lactobacillus-based preparations can improve ceramide levels in the stratum corneum, support barrier integrity, and even help reduce S. aureus colonization in atopic dermatitis.

Why is this so cool?

Basically, your skin's outer layer works as a brick wall; skin cells are bricks and ceramides are the mortar holding it together. Moisture escapes, irritants get in, and your skin gets dry and reactive when ceramide levels drop. On top of that, "bad" skin bacteria S. aureus loves to move in when your barrier is weak to make inflammation and irritation worse.

So Lactobacillus ferment is basically patching the wall and evicting the troublemaker when it boosts ceramide production and help keep S. aureus in check.

On top of all this, it also acts as a mild antimicrobial preservative booster.

Just so you know, most studies focus on specific strains or the lysate form rather than this generic "Lactobacillus Ferment", so results can vary.

Though it's a promising ingredient, it doesn't have decades of robust clinical data behind it just yet.

Lactobacillus Ferment is generally considered safe for fungal-acne prone skin. The key thing to understand is that it comes from bacteria, not yeast or fungus.

Yeast-derived ferments (like galactomyces) have been shown to activate a protein that's linked to Malassezia-related skin issues whereas lactobacillus doesn't have that problem.

Its byproducts also don't contain the types of fatty acids (C11-24 chain lengths) that Malassezia feeds on.

Leucine is a small amino acid and one of the building blocks your body uses to make proteins.

It's also naturally found in your skin as part of your Natural Moisturizing Factor (NMF). Your NMF is a mix of water-binding molecules that keeps the outer skin layer hydrated and flexible.

In skincare, it's mainly used as a skin conditioning ingredient that helps reinforce the same moisture-retention function.

You'll usually see it used at low percentages (generally under 5%) which is in line with how amino acids are used in cosmetics.

Lysine is an essential amino acid (your body cannot make it on its own). It has skin conditioning properties and one of the key players in collagen synthesis.

When your body creates collagen, lysine is basically the glue that holds everything together. It helps collagen fibers lock into each other and stay strong, with vitamin C being its trusty sidekick. Without enough lysine, this glue gets flimsy and less firm, resulting in less bouncy skin.

In skincare, lysine is mostly there to help keep your skin moisturized. It carries water through your skin's layers so everything stays plump.

So will putting lysine on your face create bouncier skin?

It's hard to say; most of the exciting collagen research on lysine comes from oral supplements or lab studies on mice. Further research is needed to truly understand what role topical lysine plays in skincare and your skin.

However, there's no harm in adding lysine to your routine as a supportive and hydrating ingredient.

Methionine is a natural amino acid your skin already uses to make proteins and gluthatione (one of the body's key defense molecules against environmental stress like sun + pollution).

Its sulfur content makes it especially reactive with the free radicals that damage skin, giving it genuine antioxidant properties.

Usage percentages are usually under 1%, and usually as part of an amino acid mix designed to mimic what's naturally in skin.

One study used a combination of essential amino acids at 0.2% with supplemental methionine added and found significantly boosted collagen production in human skin.

Cosmetic industry reviewers have looked closely at methionine and other amino acids and found them well tolerated. Methionine is actually used as a "negative control" in lab tests designed to spot irritating ingredients because it doesn't cause a reaction.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Phenylalanine is an amino acid. It is a skin soothing and hydrating ingredient. Amino acids play a crucial role in wound healing and skin hydration.

This ingredient is also used to help even out skin tone due to its ability to disrupt the melanin production process.

Two structures of phenylalanine exist: L-phenylalanine and D-phenylalanine. L-phenylalanine is essential, this means our bodies cannot produce it naturally and we must get it from foods. Our bodies convert D-phenylalanine to neurotransmitters, and D-phenylalanine is found in our bodies naturally.

Some foods that contain L-phenylalanine include eggs, soybeans, beef, milk.

Polygonum Cuspidatum Root Extract comes from the Japanese Knotweed plant native to Japan, Korea, and China.

This plant contains anti-inflammatory and antioxidant properties. It contains high amounts of resveratrol, a potent antioxidant.

The root of the plant has been used in traditional folk medicine throughout Asia.

Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.

It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.

Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.

Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.

Rosa Damascena Flower Water is the water-based byproduct of steam-distilling damask rose petals. It has skin conditioning, masking, and skin protecting properties.

Research shows that Rosa damascena is rich in flavonoids and phenolic compounds like gallic acid that contribute to its antioxidant activity.

In vitro studies have shown that Rosa damascena can scavenge free radicals and reduce melanin overproduction. Research has also found this extract offers some degree of UV absorption but this should not replace your sunscreen.

Serine is a non-essential amino acid (your body makes it on its own!). It is a major player in your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Serine is one of your NMF's most abundant components that works as a skin-identical humectant. Its hydroxyl group grabs onto water molecules to boost hydration without any heaviness or occlusion.

Research on a hydrogel with serine confirmed this serine got delivered to your stratum corneum and demonstrated enhanced skin moisturization.

Interestingly serine also helps your skin produce filaggrin, a protein that keeps your skin barrier strong and used to create collagen.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Threonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.

Our skin uses threonine for creating collagen and elastin. Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.

Tyrosine is one of the amino acids your body already uses as a protein building block. In skincare, it shows up as a skin-conditioning agent.

It's most notable for being the raw material that your skin's tyrosinase enzyme converts into melanin (skin pigment); this is why it's sometimes marketed as a "tan accelerator" in products.

However, the tanning claim is shaky. Lab studies on isolated skin cells show tyrosine can boost melanin production at fairly high concentrations but hasn't shown to speed up/deepen a tan when applied directly to skin in animal studies (up to 0.05%).

Finished cosmetic products use it at low levels (generally well under 1%). At these amounts, it's considered non-irritating and non-sensitizing based on repeat-use patch testing.

Allergy-wise, plain tyrosinase hasn't shown sensitization issues but a chemically modified relative called Oleoyl Tyrosine has had a handful of cases.

Valine is one of the essential amino acids (meaning your body can't make it on its own and has to get it from food).

In skincare, it's usually synthetically-made or pulled from plant proteins like soy.

It's one of the small building blocks that make up your skin's natural moisturizing factor (NMF), or the built-in system that helps skin hold onto water. So its main job in a formula is to give the skin gentle hydration and help it feel more comfortable.

Typical amounts are very tiny: roughly 0.00004%-0.5% in leave on products and up to 1% in rinse-off ones.

The Cosmetic Ingredient Review panel has looked at this ingredient and found no evidence of it being a skin irritant or allergen at cosmetic levels.

Vitis Vinifera Fruit Extract comes from grapes.

Grape extract has many skin benefits. It also contains many potent antioxidants such as Vitamin E , Vitamin C, proanthocyanidins, polyphenols, flavonoids, and anthocyanins. Antioxidants help protect skin. Proanthocyanidin have also been shown to help even out skin tone.

Grape extract also helps soothe and hydrate your skin.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Zanthoxylum Piperitum Fruit Extract comes from the Japanese Pepper, also known as the Prickly Ash. This plant is native to the Korean peninsula and Japan.

The pepper has antioxidant properties. It may help reduce the signs of aging.

For those with fragrance sensitivities, Zanthoxylum Piperitum Fruit Extract contains limonene.

If you have concerns, we recommend speaking with a professional about using this ingredient.

The Japanese Pepper is related to the Sichuan Pepper.

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