MEDI-PEEL Mezzo Filla Eye Serum Versus AXIS - Y Vegan Collagen Eye Serum

MEDI-PEEL Mezzo Filla Eye Serum Versus AXIS - Y Vegan Collagen Eye Serum

This anti-aging eye moisturizer is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture.

This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Pentapeptide-4 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Alcohol

Niacinamide

Dimethicone/Vinyl Dimethicone Crosspolymer

Hydroxypropyl Methylcellulose

Pullulan

Glycosyl Trehalose

Hydrogenated Starch Hydrolysate

1,2-Hexanediol

Glyceryl Acrylate/Acrylic Acid Copolymer

Sodium Hyaluronate

Propylene Glycol

Gellan Gum

Scutellaria Baicalensis Root Extract

Hydrogenated Polyisobutene

Anemarrhena Asphodeloides Root Extract

Algae Extract

Myrothamnus Flabellifolia Callus Culture Extract

Oenothera Biennis Flower Extract

Sophora Flavescens Root Extract

Thuja Orientalis Extract

Scutellaria Baicalensis Extract

Taraxacum Officinale Extract

Allantoin

Panthenol

Adenosine

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Sh-Oligopeptide-1

Sh-Oligopeptide-2

Sh-Polypeptide-1

Sh-Polypeptide-3

Sh-Polypeptide-16

Polylactic Acid

C12-14 Sec-Pareth-7

Origanum Vulgare Flower/Leaf/Stem Extract

Lavandula Angustifolia Extract

Rosmarinus Officinalis Extract

Thymus Vulgaris Extract

Porphyridium Cruentum Extract

Tromethamine

Ethylhexylglycerin

Glyceryl Caprylate

Carbomer

Cyclopentasiloxane

Dimethiconol

Chondrus Crispus Powder

Synthetic Fluorphlogopite

Agar

Titanium Dioxide

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Mica

CI 77491

Tin Oxide

Coceth-7

PPG-1-PEG-9 Lauryl Glycol Ether

PEG-40 Hydrogenated Castor Oil

Polyglyceryl-10 Laurate

Phenoxyethanol

Dipotassium Glycyrrhizate

Disodium EDTA

Parfum

Water, Glycerin, Butylene Glycol, Alcohol, Niacinamide, Dimethicone/Vinyl Dimethicone Crosspolymer, Hydroxypropyl Methylcellulose, Pullulan, Glycosyl Trehalose, Hydrogenated Starch Hydrolysate, 1,2-Hexanediol, Glyceryl Acrylate/Acrylic Acid Copolymer, Sodium Hyaluronate, Propylene Glycol, Gellan Gum, Scutellaria Baicalensis Root Extract, Hydrogenated Polyisobutene, Anemarrhena Asphodeloides Root Extract, Algae Extract, Myrothamnus Flabellifolia Callus Culture Extract, Oenothera Biennis Flower Extract, Sophora Flavescens Root Extract, Thuja Orientalis Extract, Scutellaria Baicalensis Extract, Taraxacum Officinale Extract, Allantoin, Panthenol, Adenosine, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-3, Sh-Polypeptide-16, Polylactic Acid, C12-14 Sec-Pareth-7, Origanum Vulgare Flower/Leaf/Stem Extract, Lavandula Angustifolia Extract, Rosmarinus Officinalis Extract, Thymus Vulgaris Extract, Porphyridium Cruentum Extract, Tromethamine, Ethylhexylglycerin, Glyceryl Caprylate, Carbomer, Cyclopentasiloxane, Dimethiconol, Chondrus Crispus Powder, Synthetic Fluorphlogopite, Agar, Titanium Dioxide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Mica, CI 77491, Tin Oxide, Coceth-7, PPG-1-PEG-9 Lauryl Glycol Ether, PEG-40 Hydrogenated Castor Oil, Polyglyceryl-10 Laurate, Phenoxyethanol, Dipotassium Glycyrrhizate, Disodium EDTA, Parfum

Methylpropanediol

Collagen

Hydrolyzed Hyaluronic Acid

Sodium Acetylated Hyaluronate

Tripeptide-1

Palmitoyl Pentapeptide-4

Hexapeptide-9

Acetyl Hexapeptide-8

Copper Tripeptide-1

Pyrus Malus Fruit Extract

Prunus Mume Fruit Extract

Vitis Vinifera Fruit Extract

Helianthus Annuus Seed Oil

Simmondsia Chinensis Seed Oil

Limnanthes Alba Seed Oil

Carica Papaya Fruit Extract

Centella Asiatica Extract

Ficus Carica Fruit Extract

Ulmus Davidiana Root Extract

Amaranthus Caudatus Seed Extract

Ceramide NP

Hydrogenated Lecithin

Leuconostoc/Radish Root Ferment Filtrate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

C13-14 Alkane

Sodium Acrylic Acid/Ma Copolymer

C15-23 Alkane

Decyl Glucoside

Caprylyl Glycol

Polyglyceryl-10 Stearate

Tocopherol

Water, Methylpropanediol, Glycerin, 1,2-Hexanediol, Niacinamide, Adenosine, Collagen, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Tripeptide-1, Palmitoyl Pentapeptide-4, Hexapeptide-9, Acetyl Hexapeptide-8, Copper Tripeptide-1, Pyrus Malus Fruit Extract, Prunus Mume Fruit Extract, Vitis Vinifera Fruit Extract, Helianthus Annuus Seed Oil, Simmondsia Chinensis Seed Oil, Limnanthes Alba Seed Oil, Carica Papaya Fruit Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Ceramide NP, Hydrogenated Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, C13-14 Alkane, Sodium Acrylic Acid/Ma Copolymer, C15-23 Alkane, Ethylhexylglycerin, Decyl Glucoside, Caprylyl Glycol, Polyglyceryl-10 Stearate, Tocopherol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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