MediCube Age-R Booster Gel Serum Versus MediCube AGE-R Collagen Booster Gel Serum

MediCube Age-R Booster Gel Serum Versus MediCube AGE-R Collagen Booster Gel Serum

This anti-aging serum is formulated around Niacinamide and Sodium Hyaluronate to soften the look of wrinkles and hydrate skin.

This anti-aging serum is formulated around Niacinamide and Adenosine to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Propanediol

Niacinamide

1,2-Hexanediol

Adenium Obesum Leaf Cell Extract

Jasminum Sambac Leaf Cell Extract

Sodium Hyaluronate

Soluble Collagen

Hydrolyzed Hyaluronic Acid

Hyaluronic Acid

Pentylene Glycol

Sodium Polyacryloyldimethyl Taurate

Glycerin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Caprylyl Glycol

Ethylhexylglycerin

Dipotassium Glycyrrhizate

Adenosine

Sodium Phytate

Glyceryl Acrylate/Acrylic Acid Copolymer

Pvm/Ma Copolymer

Sodium Polyacrylate

Butylene Glycol

Sodium Chloride

Tocopherol

Sodium Bicarbonate

Calcium Chloride

Potassium Chloride

Hydroxypropyltrimonium Hyaluronate

Sodium Acetylated Hyaluronate

Hydrolyzed Sodium Hyaluronate

Sodium Hyaluronate Crosspolymer

Potassium Hyaluronate

Water, Propanediol, Niacinamide, 1,2-Hexanediol, Adenium Obesum Leaf Cell Extract, Jasminum Sambac Leaf Cell Extract, Sodium Hyaluronate, Soluble Collagen, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Pentylene Glycol, Sodium Polyacryloyldimethyl Taurate, Glycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Caprylyl Glycol, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Adenosine, Sodium Phytate, Glyceryl Acrylate/Acrylic Acid Copolymer, Pvm/Ma Copolymer, Sodium Polyacrylate, Butylene Glycol, Sodium Chloride, Tocopherol, Sodium Bicarbonate, Calcium Chloride, Potassium Chloride, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate

Methylpropanediol

Glycereth-26

Polyglycerin-3

Methyl Gluceth-20

Methyl Gluceth-10

Caprylic/Capric Triglyceride

Allantoin

C12-14 Pareth-12

Soluble Elastin

Parfum

Eclipta Prostrata Extract

Melia Azadirachta Leaf Extract

Moringa Oleifera Seed Oil

Phosphatidylcholine

Sodium DNA

Atelocollagen

Desamido Collagen

Ceramide NP

Prunella Vulgaris Extract

Fucus Vesiculosus Extract

Hydrolyzed Collagen

Collagen

Collagen Amino Acids

Glycine

Serine

Procollagen

Glutamic Acid

Lysine

Alanine

Threonine

Proline

Arginine

Water, Methylpropanediol, Glycereth-26, Glycerin, Niacinamide, 1,2-Hexanediol, Polyglycerin-3, Methyl Gluceth-20, Methyl Gluceth-10, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Allantoin, C12-14 Pareth-12, Soluble Elastin, Ethylhexylglycerin, Parfum, Adenosine, Sodium Hyaluronate, Eclipta Prostrata Extract, Butylene Glycol, Melia Azadirachta Leaf Extract, Soluble Collagen, Moringa Oleifera Seed Oil, Phosphatidylcholine, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium DNA, Atelocollagen, Desamido Collagen, Ceramide NP, Prunella Vulgaris Extract, Fucus Vesiculosus Extract, Hydrolyzed Collagen, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Collagen, Collagen Amino Acids, Glycine, Serine, Procollagen, Glutamic Acid, Lysine, Alanine, Threonine, Proline, Arginine

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

This ingredient is created by putting sodium hyaluronate through hydrolysis.

You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.

According to studies, low molecular-weight hyaluronic acid can:

One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.

Hydrolysis is a process of changing a molecule using water or enzymes.

This ingredient is water-soluble.

Hydroxypropyltrimonium Hyaluronate is a positively charged version of hyaluronic acid.

This small change does a lot in a formula:

Regular hyaluronic acid carries a negative charge and so does the surface of your skin. This means the two repel each other and hyaluronic acid can be washed away easily. The positive charge here does the opposite: it makes the ingredient cling to your skin (also called "substantivity") so it keeps hydrating even in rinse-off products where it lays down a light, moisture-holding film.

The research backs this up too; a 2025 clinical study on a shower gel containing 0.1% positively charged hyaluronic acid increased skin hydration by 6.6% versus the baseline and 11.1% versus the placebo. This was measured 6 hours after 1 minute of contact and rinse, and on volunteers with very dry skin.

The same team's lab work showed it adhered to skin far better than unmodified hyaluronic acid (+107% vs. low molecular weight, +23% versus high molecular weight). They also found it increased two proteins tied to skin hydration, aquaporin-3 by 16% and filaggrin by 35%.

A separate 2024 study reached a similar conclusion and credited the hydrating benefits to its film-forming properties.

Both studies used the ingredient at 0.1% which also matches how much it usually shows up in products (at fractions of a percent).

One honesty note worth keeping in mind: the published research comes from the company that manufactures the ingredient so independent data would strengthen the picture. However, the results are consistent and the mechanism makes sense.

As a Hyaluronic Acid derivative, it has a well-tolerated profile and suits most skin types.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Sodium Acetylated Hyaluronate is a type of Hyaluronic Acid.

Hyaluronic Acids help moisturize, soothe, and protect the skin.

Read about common types of Hyaluronic Acid here:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.

A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.

A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.

More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.

Soluble collagen is a large, water-loving protein typically extracted from cattle hides or marine sources like fish skin.

In cosmetics, it works purely as a humectant and film-former.

Despite the marketing that surrounds the word "collagen", its molecule is far too large to penetrate skin so it can't rebuild the collagen in your dermis.

Instead, it sits on the surface and binds water to help reduce transepidermal water loss and leave skin feeling soft, plump, and temporarily tightened.

Suppliers commonly recommend using it around 3-6% though industry data shows concentrations are often much lower (down to a fraction of a percent).

This ingredient has been found safe to use in cosmetics with no reported irritation, sensitization, or phototoxicity.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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