MediCube Exosome Cica Cream Versus MediCube PDRN Pink Collagen Capsule Cream

MediCube Exosome Cica Cream Versus MediCube PDRN Pink Collagen Capsule Cream

This calming moisturizer is formulated around Panthenol and Ectoin to calm redness and strengthen the skin barrier.

This anti-aging moisturizer is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Butylene Glycol

Glycerin

Caprylic/Capric Triglyceride

Cyclohexasiloxane

Pentylene Glycol

1,2-Hexanediol

Dipropylene Glycol

Ethylhexyl Olivate

Panthenol

Ectoin

Hydrogenated Polydecene

Limnanthes Alba Seed Oil

Sodium Acrylates Copolymer

Theobroma Grandiflorum Seed Butter

Cetearyl Olivate

Polyglyceryl-4 Oleate

Sorbitan Olivate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Synthetic Beeswax

Dimethicone/Vinyl Dimethicone Crosspolymer

Hydroxyacetophenone

Xanthan Gum

Ethylhexylglycerin

Melia Azadirachta Leaf Extract

Dipotassium Glycyrrhizate

Melia Azadirachta Flower Extract

Sodium Phytate

Ocimum Sanctum Leaf Extract

Sorbitan Isostearate

Allantoin

Hydrolyzed Hyaluronic Acid

Hydrogenated Lecithin

Silica

Curcuma Longa Root Extract

Dextrin

Theobroma Cacao Extract

Centella Asiatica Leaf Water

Corallina Officinalis Extract

Polyglyceryl-10 Stearate

Glycyrrhiza Uralensis Extract

Tocopherol

Ceramide NP

Centella Asiatica Extract

Centella Asiatica Leaf Extract

Centella Asiatica Root Extract

Caprylyl/Capryl Glucoside

Centella Asiatica Leaf

Madecassoside

Phytosterols

Hydrolyzed Vegetable Protein

Lactobacillus Ferment Filtrate

Saccharide Isomerate

Vegetable Amino Acids

Asiaticoside

Asiatic Acid

Madecassic Acid

Water, Butylene Glycol, Glycerin, Caprylic/Capric Triglyceride, Cyclohexasiloxane, Pentylene Glycol, 1,2-Hexanediol, Dipropylene Glycol, Ethylhexyl Olivate, Panthenol, Ectoin, Hydrogenated Polydecene, Limnanthes Alba Seed Oil, Sodium Acrylates Copolymer, Theobroma Grandiflorum Seed Butter, Cetearyl Olivate, Polyglyceryl-4 Oleate, Sorbitan Olivate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Synthetic Beeswax, Dimethicone/Vinyl Dimethicone Crosspolymer, Hydroxyacetophenone, Xanthan Gum, Ethylhexylglycerin, Melia Azadirachta Leaf Extract, Dipotassium Glycyrrhizate, Melia Azadirachta Flower Extract, Sodium Phytate, Ocimum Sanctum Leaf Extract, Sorbitan Isostearate, Allantoin, Hydrolyzed Hyaluronic Acid, Hydrogenated Lecithin, Silica, Curcuma Longa Root Extract, Dextrin, Theobroma Cacao Extract, Centella Asiatica Leaf Water, Corallina Officinalis Extract, Polyglyceryl-10 Stearate, Glycyrrhiza Uralensis Extract, Tocopherol, Ceramide NP, Centella Asiatica Extract, Centella Asiatica Leaf Extract, Centella Asiatica Root Extract, Caprylyl/Capryl Glucoside, Centella Asiatica Leaf, Madecassoside, Phytosterols, Hydrolyzed Vegetable Protein, Lactobacillus Ferment Filtrate, Saccharide Isomerate, Vegetable Amino Acids, Asiaticoside, Asiatic Acid, Madecassic Acid

Niacinamide

Methylpropanediol

Propanediol

Glycereth-26

Arginine

Ethylhexyl Palmitate

Cetearyl Alcohol

Carbomer

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Simethicone

Eclipta Prostrata Extract

Adenosine

Polyacrylate-13

Sodium DNA

Disodium EDTA

Polyisobutene

Hydrolyzed Sclerotium Gum

Glyceryl Stearate

Moringa Oleifera Seed Oil

Polysorbate 20

Sodium Hyaluronate

Glutathione

Octyldodecanol

Hydroxypropyltrimonium Hyaluronate

Salmon Egg Extract

Cyanocobalamin

Thioctic Acid

Hydrolyzed Collagen Extract

Sodium Acetylated Hyaluronate

Acetyl Hexapeptide-8

Copper Tripeptide-1

Hyaluronic Acid

Caprylyl Glycol

Palmitoyl Pentapeptide-4

Hydrolyzed Sodium Hyaluronate

Palmitoyl Hexapeptide-12

Sodium Hyaluronate Crosspolymer

Potassium Hyaluronate

Water, Glycerin, Niacinamide, Methylpropanediol, Propanediol, 1,2-Hexanediol, Dipropylene Glycol, Caprylic/Capric Triglyceride, Glycereth-26, Arginine, Butylene Glycol, Ethylhexyl Palmitate, Cetearyl Alcohol, Carbomer, Cetearyl Olivate, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Simethicone, Eclipta Prostrata Extract, Ethylhexylglycerin, Adenosine, Polyacrylate-13, Sodium DNA, Disodium EDTA, Melia Azadirachta Leaf Extract, Polyisobutene, Hydrolyzed Sclerotium Gum, Glyceryl Stearate, Moringa Oleifera Seed Oil, Polysorbate 20, Sorbitan Isostearate, Sodium Hyaluronate, Glutathione, Octyldodecanol, Hydroxypropyltrimonium Hyaluronate, Salmon Egg Extract, Hydrogenated Lecithin, Ceramide NP, Cyanocobalamin, Thioctic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Collagen Extract, Sodium Acetylated Hyaluronate, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Pentapeptide-4, Hydrolyzed Sodium Hyaluronate, Palmitoyl Hexapeptide-12, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.

You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.

These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.

This ingredient is well-tolerated and has no significant sensitization data.

Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

This ingredient is also known as neem leaf extract. It contains natural compounds like nimbidin, quercetin, and other polyphenols that give it antibacterial, antifungal, and anti-inflammatory activity.

Lab studies have shown neem leaf extract can inhibit acne-related bacteria and help calm skin. Animal studies on wound gels using 1-3% neem leaf extract found it sped up healing without causing irritation.

A wound-healing study testing gels with the extract at 1%, 2%, and 3% concentrations and found none of them irritated the skin.

Most commercial products also use it in a similar low range (typically under 5%).

Allergy-wise, there are some case reports on neem oil causing allergic contact dermatitis so people with plant/botanical sensitivities may want to patch test first.

Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.

As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.

In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.

Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.

This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.

According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.

Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.

Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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