MediCube Triple Collagen Cream Versus MediCube PDRN Pink Collagen Capsule Cream

MediCube Triple Collagen Cream Versus MediCube PDRN Pink Collagen Capsule Cream

This anti-aging moisturizer is formulated around Niacinamide and Collagen Extract to soften the look of wrinkles and hydrate skin.

This anti-aging moisturizer is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dipropylene Glycol

Cetearyl Alcohol

Cyclopentasiloxane

Caprylic/Capric Triglyceride

Triethylhexanoin

Hydrogenated Polydecene

1,2-Hexanediol

Niacinamide

Hydrogenated Poly(C6-14 Olefin)

Cyclohexasiloxane

Glyceryl Stearate Se

Dioscorea Japonica Root Extract

Aesculus Hippocastanum Extract

Laminaria Japonica Extract

Eclipta Prostrata Leaf Extract

Collagen Extract

Hydrogenated Lecithin

Argania Spinosa Kernel Oil

Sodium Hyaluronate

Cetearyl Olivate

C12-16 Alcohols

Dimethicone

Glyceryl Stearate

PEG-100 Stearate

Microcrystalline Cellulose

Cetearyl Glucoside

Sorbitan Olivate

Fructose

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Butylene Glycol

Squalane

Palmitic Acid

Betaine

Cellulose Gum

Hydrolyzed Corn Starch

Polysorbate 60

Ethylhexylglycerin

Adenosine

Hydrogenated Polyisobutene

Beta-Glucan

Alcohol

Disodium EDTA

Isononyl Isononanoate

Polyglyceryl-10 Stearate

Sorbitan Isostearate

Sucrose

Stearic Acid

Butyrospermum Parkii Butter

Polyglyceryl-2 Dipolyhydroxystearate

Fructooligosaccharides

Inulin Lauryl Carbamate

Hydrolyzed Hyaluronic Acid

Citric Acid

Disodium Stearoyl Glutamate

Collagen

Hydrolyzed Elastin

Hyaluronic Acid

Tocopherol

Leuconostoc/Radish Root Ferment Filtrate

Parfum

Potassium Sorbate

Linalool

Benzyl Salicylate

Limonene

Hydroxycitronellal

Water, Glycerin, Dipropylene Glycol, Cetearyl Alcohol, Cyclopentasiloxane, Caprylic/Capric Triglyceride, Triethylhexanoin, Hydrogenated Polydecene, 1,2-Hexanediol, Niacinamide, Hydrogenated Poly(C6-14 Olefin), Cyclohexasiloxane, Glyceryl Stearate Se, Dioscorea Japonica Root Extract, Aesculus Hippocastanum Extract, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Collagen Extract, Hydrogenated Lecithin, Argania Spinosa Kernel Oil, Sodium Hyaluronate, Cetearyl Olivate, C12-16 Alcohols, Dimethicone, Glyceryl Stearate, PEG-100 Stearate, Microcrystalline Cellulose, Cetearyl Glucoside, Sorbitan Olivate, Fructose, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Butylene Glycol, Squalane, Palmitic Acid, Betaine, Cellulose Gum, Hydrolyzed Corn Starch, Polysorbate 60, Ethylhexylglycerin, Adenosine, Hydrogenated Polyisobutene, Beta-Glucan, Alcohol, Disodium EDTA, Isononyl Isononanoate, Polyglyceryl-10 Stearate, Sorbitan Isostearate, Sucrose, Stearic Acid, Butyrospermum Parkii Butter, Polyglyceryl-2 Dipolyhydroxystearate, Fructooligosaccharides, Inulin Lauryl Carbamate, Hydrolyzed Hyaluronic Acid, Citric Acid, Disodium Stearoyl Glutamate, Collagen, Hydrolyzed Elastin, Hyaluronic Acid, Tocopherol, Leuconostoc/Radish Root Ferment Filtrate, Parfum, Potassium Sorbate, Linalool, Benzyl Salicylate, Limonene, Hydroxycitronellal

Methylpropanediol

Propanediol

Glycereth-26

Arginine

Ethylhexyl Palmitate

Carbomer

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Simethicone

Eclipta Prostrata Extract

Polyacrylate-13

Sodium DNA

Melia Azadirachta Leaf Extract

Polyisobutene

Hydrolyzed Sclerotium Gum

Moringa Oleifera Seed Oil

Polysorbate 20

Glutathione

Octyldodecanol

Hydroxypropyltrimonium Hyaluronate

Salmon Egg Extract

Ceramide NP

Cyanocobalamin

Thioctic Acid

Hydrolyzed Collagen Extract

Sodium Acetylated Hyaluronate

Acetyl Hexapeptide-8

Copper Tripeptide-1

Caprylyl Glycol

Palmitoyl Pentapeptide-4

Hydrolyzed Sodium Hyaluronate

Palmitoyl Hexapeptide-12

Sodium Hyaluronate Crosspolymer

Potassium Hyaluronate

Water, Glycerin, Niacinamide, Methylpropanediol, Propanediol, 1,2-Hexanediol, Dipropylene Glycol, Caprylic/Capric Triglyceride, Glycereth-26, Arginine, Butylene Glycol, Ethylhexyl Palmitate, Cetearyl Alcohol, Carbomer, Cetearyl Olivate, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Simethicone, Eclipta Prostrata Extract, Ethylhexylglycerin, Adenosine, Polyacrylate-13, Sodium DNA, Disodium EDTA, Melia Azadirachta Leaf Extract, Polyisobutene, Hydrolyzed Sclerotium Gum, Glyceryl Stearate, Moringa Oleifera Seed Oil, Polysorbate 20, Sorbitan Isostearate, Sodium Hyaluronate, Glutathione, Octyldodecanol, Hydroxypropyltrimonium Hyaluronate, Salmon Egg Extract, Hydrogenated Lecithin, Ceramide NP, Cyanocobalamin, Thioctic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Collagen Extract, Sodium Acetylated Hyaluronate, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Pentapeptide-4, Hydrolyzed Sodium Hyaluronate, Palmitoyl Hexapeptide-12, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.

You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.

These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.

This ingredient is well-tolerated and has no significant sensitization data.

Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.

Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.

This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.

A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.

Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.

Fun fact: The human body also creates Glyceryl Stearate naturally.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.

As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.

In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.

Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.

This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.

According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.

Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.

Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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