Collagen & Peptide NutritionNutrition and collagen guides

Nutrition guide

Missha Atelo Collagen 500 Power Plumping Cream Versus Mizon Collagen Power Lifting Cream

Missha Atelo Collagen 500 Power Plumping Cream Versus Mizon Collagen Power Lifting Cream This anti-aging moisturizer is formulated around Hydrolyzed Collagen Extract and Niacinamide to soften the look of wrinkles. This anti-aging moisturizer is formulated arou

Missha Atelo Collagen 500 Power Plumping Cream Versus Mizon Collagen Power Lifting Cream

This anti-aging moisturizer is formulated around Hydrolyzed Collagen Extract and Niacinamide to soften the look of wrinkles.

This anti-aging moisturizer is formulated around Houttuynia Cordata Extract and Copper Tripeptide-1 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Hydrolyzed Collagen Extract

Hydrogenated Polydecene

Glycerin

Dipropylene Glycol

Caprylic/Capric Triglyceride

Glyceryl Stearate

Cyclohexasiloxane

Pentaerythrityl Tetraethylhexanoate

Niacinamide

Cetearyl Alcohol

Polyglyceryl-6 Diisostearate

Water

Dicaprylyl Ether

Panthenol

Phellodendron Amurense Bark Extract

Olea Europaea Fruit Oil

Citrus Aurantium Bergamia Fruit Oil

Pelargonium Graveolens Flower Oil

Lavandula Angustifolia Oil

Anthemis Nobilis Flower Oil

Citrus Aurantium Dulcis Peel Oil

Juniperus Mexicana Oil

Macadamia Integrifolia Seed Oil

Elaeis Guineensis Oil

Helianthus Annuus Seed Oil

Hydrogenated Lecithin

Soluble Collagen

Polyglyceryl-10 Laurate

Hydrolyzed Collagen

Beeswax

Sodium Stearoyl Glutamate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Jojoba Esters

Cetyl Alcohol

Polyglyceryl-3 Beeswax

Xanthan Gum

Hydrolyzed Elastin

Adenosine

Disodium EDTA

Sorbitan Isostearate

Sodium Laurate

Butylene Glycol

Lauric Acid

Arginine/Lysine Polypeptide

Cyanocobalamin

Pentaerythrityl Tetraisostearate

Ceramide NP

Tetrahydropiperine

Elastin

Phospholipids

Hyaluronic Acid

Silica Dimethyl Silylate

Sorbic Acid

Sodium Chondroitin Sulfate

Atelocollagen

Magnesium PCA

Copper Tripeptide-1

1-Methylhydantoin-2-Imide

Glycine

Glucosamine Hcl

Glutamic Acid

Glutamine

Dipotassium Phosphate

Lysine

Leucine

Magnesium Citrate

Magnesium Chloride

Methionine

Valine

Serine

Sucrose

Cysteine

Citrulline

Sea Salt

Asparagine

Aspartic Acid

Isoleucine

Alanine

Arginine

Calcium Chloride

Taurine

Tyrosine

Threonine

Tryptophan

Phenylalanine

Proline

Histidine

1,2-Hexanediol

Phytosphingosine

Hydroxyacetophenone

Ethylhexylglycerin

Pentylene Glycol

Formic Acid

Limonene

Linalool

Citronellol

Geraniol

Citral

Hydrolyzed Collagen Extract, Hydrogenated Polydecene, Glycerin, Dipropylene Glycol, Caprylic/Capric Triglyceride, Glyceryl Stearate, Cyclohexasiloxane, Pentaerythrityl Tetraethylhexanoate, Niacinamide, Cetearyl Alcohol, Polyglyceryl-6 Diisostearate, Water, Dicaprylyl Ether, Panthenol, Phellodendron Amurense Bark Extract, Olea Europaea Fruit Oil, Citrus Aurantium Bergamia Fruit Oil, Pelargonium Graveolens Flower Oil, Lavandula Angustifolia Oil, Anthemis Nobilis Flower Oil, Citrus Aurantium Dulcis Peel Oil, Juniperus Mexicana Oil, Macadamia Integrifolia Seed Oil, Elaeis Guineensis Oil, Helianthus Annuus Seed Oil, Hydrogenated Lecithin, Soluble Collagen, Polyglyceryl-10 Laurate, Hydrolyzed Collagen, Beeswax, Sodium Stearoyl Glutamate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Jojoba Esters, Cetyl Alcohol, Polyglyceryl-3 Beeswax, Xanthan Gum, Hydrolyzed Elastin, Adenosine, Disodium EDTA, Sorbitan Isostearate, Sodium Laurate, Butylene Glycol, Lauric Acid, Arginine/Lysine Polypeptide, Cyanocobalamin, Pentaerythrityl Tetraisostearate, Ceramide NP, Tetrahydropiperine, Elastin, Phospholipids, Hyaluronic Acid, Silica Dimethyl Silylate, Sorbic Acid, Sodium Chondroitin Sulfate, Atelocollagen, Magnesium PCA, Copper Tripeptide-1, 1-Methylhydantoin-2-Imide, Glycine, Glucosamine Hcl, Glutamic Acid, Glutamine, Dipotassium Phosphate, Lysine, Leucine, Magnesium Citrate, Magnesium Chloride, Methionine, Valine, Serine, Sucrose, Cysteine, Citrulline, Sea Salt, Asparagine, Aspartic Acid, Isoleucine, Alanine, Arginine, Calcium Chloride, Taurine, Tyrosine, Threonine, Tryptophan, Phenylalanine, Proline, Histidine, 1,2-Hexanediol, Phytosphingosine, Hydroxyacetophenone, Ethylhexylglycerin, Pentylene Glycol, Formic Acid, Limonene, Linalool, Citronellol, Geraniol, Citral

Houttuynia Cordata Extract

Trehalose

Royal Jelly

Dextrin

Polyisobutene

Theobroma Cacao Extract

BHT

Beta-Glucan

Polyacrylate-13

Polysorbate 20

Phenoxyethanol

Cetearyl Dimethicone Crosspolymer

Cyclopentasiloxane

Propanediol

Iris Florentina Root Extract

Dimethicone

Coptis Chinensis Root Extract

Salvia Hispanica Seed Extract

Bis-PEG-18 Methyl Ether Dimethyl Silane

Centella Asiatica Extract

Prunus Amygdalus Dulcis Seed Extract

Propolis Extract

Carbomer

Hydrolyzed Royal Jelly Protein

Sodium Hyaluronate

Tromethamine

Water, Hydrolyzed Collagen, Houttuynia Cordata Extract, Trehalose, Sorbitan Isostearate, Royal Jelly, Dextrin, Copper Tripeptide-1, Polyisobutene, Theobroma Cacao Extract, BHT, Glycerin, Beta-Glucan, Polyacrylate-13, Polysorbate 20, Phenoxyethanol, Cetearyl Dimethicone Crosspolymer, Cyclopentasiloxane, Propanediol, Iris Florentina Root Extract, Dimethicone, Adenosine, Coptis Chinensis Root Extract, Salvia Hispanica Seed Extract, Ethylhexylglycerin, Xanthan Gum, Bis-PEG-18 Methyl Ether Dimethyl Silane, Centella Asiatica Extract, Prunus Amygdalus Dulcis Seed Extract, Propolis Extract, Carbomer, Butylene Glycol, Hydrolyzed Royal Jelly Protein, 1,2-Hexanediol, Cyclohexasiloxane, Disodium EDTA, Sodium Hyaluronate, Tromethamine

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Cyclohexasiloxane is a type of silicone more commonly known as D6. It is an emollient and solvent.

Cyclohexasiloxane is used to evenly distribute ingredients throughout the product. When applied to the skin, Cyclohexasiloxane evaporates and leaves behind a silky feel.

As an emollient, it can help the skin feel soft and hydrated. It is also used to reduce frizz in hair products.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations.

In a formula, it works mainly as a skin-conditioning and moisturizing agent.

The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper.

This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides.

It's worth being realistic here:

Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studies, not topicals).

However, recent lab and skin-model work on Hydrolyzed Fish Collagen has shown promising effects on cell viability and wound healing when used as an active.

Typical concentrations range from 0.2-2%, but the percentage can go much higher in rinse-off or hair products (sometimes even above 50%).

Clinical studies on this ingredient showed no irritation, sensitization, or phototoxicity.

If you are looking for vegan collagen, it usually goes by a different INCI name like hydrolyzed soy protein. Vegan collagen is derived from yeast, bacteria, or plant sources.

The results are varied.

A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.

However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.

Further studies are needed at this time.

Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.

As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.

In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.

Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

SUPPLEMENTAL FIELD FILE

Notes to carry forward.

Source-derived references linked through this guide’s public topic markers.

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PROVISION SHELF

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