Collagen & Peptide NutritionNutrition and collagen guides

Nutrition guide

Mizon Only One Eye Cream For Face Versus Stay Well Vegan Collagen Eye Cream

Mizon Only One Eye Cream For Face Versus Stay Well Vegan Collagen Eye Cream This anti-aging eye moisturizer is formulated around Niacinamide and Madecassoside to soften the look of wrinkles and strengthen the skin barrier. This anti-aging eye moisturizer is fo

Mizon Only One Eye Cream For Face Versus Stay Well Vegan Collagen Eye Cream

This anti-aging eye moisturizer is formulated around Niacinamide and Madecassoside to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging eye moisturizer is formulated around Bakuchiol and Palmitoyl Pentapeptide-4 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Cyclopentasiloxane

Propanediol

Dimethicone

Butyrospermum Parkii Butter

Niacinamide

1,2-Hexanediol

Cetearyl Olivate

Coco-Caprylate/Caprate

Polysorbate 20

Polyacrylate-13

Sorbitan Olivate

Polyisobutene

Dimethicone/Vinyl Dimethicone Crosspolymer

Butylene Glycol

Sodium Polyacrylate

Dimethiconol

Squalane

Pullulan

Dipotassium Glycyrrhizate

Sodium Hyaluronate

Palmitoyl Glycine

Moringa Oleifera Seed Oil

Caprylic/Capric Triglyceride

Helianthus Annuus Seed Oil Unsaponifiables

Lecithin

Madecassoside

Citric Acid

Beta-Glucan

Sodium Ascorbyl Phosphate

Acetyl Hexapeptide-8

Copper Tripeptide-1

Palmitoyl Pentapeptide-4

Asiatic Acid

Asiaticoside

Madecassic Acid

Adenosine

Xanthan Gum

Sorbitan Isostearate

Eclipta Prostrata Extract

Allantoin

Centella Asiatica Extract

Melia Azadirachta Leaf Extract

Chamaecyparis Obtusa Leaf Extract

Origanum Vulgare Leaf Extract

Salix Alba Bark Extract

Cinnamomum Cassia Bark Extract

Lactobacillus/Soybean Ferment Extract

Portulaca Oleracea Extract

Scutellaria Baicalensis Root Extract

Ethylhexylglycerin

Disodium EDTA

Parfum

Water, Glycerin, Cyclopentasiloxane, Propanediol, Dimethicone, Butyrospermum Parkii Butter, Niacinamide, 1,2-Hexanediol, Cetearyl Olivate, Coco-Caprylate/Caprate, Polysorbate 20, Polyacrylate-13, Sorbitan Olivate, Polyisobutene, Dimethicone/Vinyl Dimethicone Crosspolymer, Butylene Glycol, Sodium Polyacrylate, Dimethiconol, Squalane, Pullulan, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Palmitoyl Glycine, Moringa Oleifera Seed Oil, Caprylic/Capric Triglyceride, Helianthus Annuus Seed Oil Unsaponifiables, Lecithin, Madecassoside, Citric Acid, Beta-Glucan, Sodium Ascorbyl Phosphate, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Asiatic Acid, Asiaticoside, Madecassic Acid, Adenosine, Xanthan Gum, Sorbitan Isostearate, Eclipta Prostrata Extract, Allantoin, Centella Asiatica Extract, Melia Azadirachta Leaf Extract, Chamaecyparis Obtusa Leaf Extract, Origanum Vulgare Leaf Extract, Salix Alba Bark Extract, Cinnamomum Cassia Bark Extract, Lactobacillus/Soybean Ferment Extract, Portulaca Oleracea Extract, Scutellaria Baicalensis Root Extract, Ethylhexylglycerin, Disodium EDTA, Parfum

Cetearyl Glucoside

Cetyl Alcohol

Cetyl Palmitate

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Sorbitan Palmitate

Cetearyl Alcohol

Stearyl Alcohol

Wheat Amino Acids

Myristyl Alcohol

Sorbitan Oleate

Caprylyl/Capryl Glucoside

Lauryl Alcohol

Natto Gum

Bakuchiol

Oligopeptide-32

Oligopeptide-29

Water, Butylene Glycol, Glycerin, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Sorbitan Olivate, Cetearyl Glucoside, Cetyl Alcohol, Cetyl Palmitate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Palmitate, Cetearyl Alcohol, Polyisobutene, Stearyl Alcohol, Wheat Amino Acids, Ethylhexylglycerin, Myristyl Alcohol, Sorbitan Oleate, Caprylyl/Capryl Glucoside, Parfum, Lauryl Alcohol, Disodium EDTA, Natto Gum, Bakuchiol, Palmitoyl Pentapeptide-4, Oligopeptide-32, Copper Tripeptide-1, Acetyl Hexapeptide-8, Oligopeptide-29

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

You might know this ingredient as Matrixyl. It is a synthetic peptide made up of five amino acids attached to a palmitic acid, a fatty acid that helps it absorb into skin more easily.

As a signal peptide, Matrixyl acts like a little messenger. Once it reaches your skin cells, it tells them to ramp up production of collagen, elastin, and other proteins that keep skin looking firm and smooth.

A 12 week clinical study found that a moisturizer containing just 3 ppm of Matrixyl led to a significant improvement in fine-lines and wrinkles. Another study showed an 18% reduction in wrinkle depth, 37% reduction in wrinkle thickness, and a 21% improvement in skin firmness after just 28 days of twice-daily use.

The coolest part is that it works at incredibly low concentrations (like 0.0003%) and it plays well with other actives.

The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization.

Fun fact: Matrixyl was originally developed by French company Sederma and Procter & Gamble.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Polyisobutene is a synthetic polymer made from isobutene.

It is a film-forming agent and helps bind ingredients together.

Polyisobutene is not absorbed by the skin.

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.

This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.

According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.

Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.

Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

SUPPLEMENTAL FIELD FILE

Notes to carry forward.

Source-derived references linked through this guide’s public topic markers.

01
REFERENCE CARDS

Ingredients, lists & structured values

INGREDIENT LIST

Ingredients Explained

  • These ingredients are found in both products.
  • Ingredients higher up in an ingredient list are typically present in a larger amount.
  • Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
  • Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
  • However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
  • Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
  • In skincare formulas, citric acid can:
  • While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
  • Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
  • Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
  • However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is u…
  • Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  • Topically, glycerin does several things at once:
  • Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  • Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  • This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  • Just know very high concentrations (>40%) can feel tacky in low humidity.
  • Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Source trail · skinsort.com →
05
PROVISION SHELF

Products & side-by-side records

Product

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Source: skinsort.comOpen reference →