Therapeutic peptides in the treatment of digestive inflammation
Skip to main content Skip to article View PDF Under a Creative Commons license Open access Abstract Digestive inflammation is a widespread global issue that significantly impacts quality of life. Recent advances have highlighted the unique potential of therape
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Under a Creative Commons license
Open access
Abstract
Digestive inflammation is a widespread global issue that significantly impacts quality of life. Recent advances have highlighted the unique potential of therapeutic peptides for treating this condition, owing to their specific bioactivity and high specificity. By specifically targeting key proteins involved in the pathological process and modulating biomolecular functions, therapeutic peptides offer a novel and promising approach to managing digestive inflammation. This review explores the development history, pharmacological characteristics, clinical applications, and regulatory mechanisms of therapeutic peptides in treating digestive inflammation. Additionally, the review addresses pharmacokinetics and quality control methods of therapeutic peptides, focusing on challenges such as low bioavailability, poor stability, and difficulties in delivery. The role of modern biotechnologies and nanotechnologies in overcoming these challenges is also examined. Finally, future directions for therapeutic peptides and their potential impact on clinical applications are discussed, with emphasis placed on their significant role in advancing medical and therapeutic practices.
Keywords
Digestive inflammation
Therapeutic peptides
Regulatory mechanism
Molecular targets
Pharmacokinetics
Quality control
Clinical applications
1These authors contributed equally to this work.
© 2024 The Authors. Published by Elsevier Ltd.